Cannabis Observational Study on Mood, Inflammation, and Cognition
الكلمات الدالة
نبذة مختصرة
وصف
Cannabis research can be dated back to the 1970's where standardized smoking of low potency cannabis in a laboratory setting has been the primary method used to understand the effects of the drug. The objective of this program is to use a naturalistic design to advance a more nuanced understanding of the potential outcomes associated with using different strains of marijuana. Researchers need to understand the effects of commonly used cannabis strains, as they are used in every day life. Commonly available strains of cannabis sold in dispensaries in Colorado have 3-5 times greater potency of cannabinoids, such as the psychoactive compound tetrahydrocannabinol (THC), than what has been used in laboratory settings. It is possible that laboratory based studies underestimate the effects of more potent strains that are widely available. Also, scientists have focused on the effects of THC while mostly ignoring other major cannabinoids (e.g. cannabidiol or CBD) and their synergistic relationship.
The objective of this study is to observe how different strains of marijuana, based off their unique cannabinoid content, can influence your mental and physical state in real time. This program will allow researchers to observe these effects immediately before and after cannabis use. A participant will use cannabis in the comfort of their home, and will walk out their front door and into a mobile lab that will be parked outside of their house. In this study, there is no need to smoke and drive.
Participation is this study involves one appointment at the laboratory facility in Boulder and one appointment in the mobile laboratory.
تواريخ
| آخر التحقق: | 07/31/2018 |
| تم الإرسال لأول مرة: | 04/29/2018 |
| تم إرسال التسجيل المقدر: | 04/29/2018 |
| أول نشر: | 05/10/2018 |
| تم إرسال آخر تحديث: | 08/05/2018 |
| آخر تحديث تم نشره: | 08/06/2018 |
| تاريخ بدء الدراسة الفعلي: | 06/30/2016 |
| تاريخ الإنجاز الأساسي المقدر: | 11/29/2020 |
| التاريخ المتوقع لانتهاء الدراسة: | 04/29/2021 |
حالة أو مرض
مرحلة
معايير الأهلية
| الأعمار المؤهلة للدراسة | 21 Years إلى 21 Years |
| الأجناس المؤهلة للدراسة | All |
| طريقة أخذ العينات | Non-Probability Sample |
| يقبل المتطوعين الأصحاء | نعم |
| المعايير | Inclusion Criteria: - Have prior experience with edibles - Have used marijuana in the past month. This includes any form of marijuana consumption including flower, oil, wax, tinctures and edibles - Not using other drugs (cocaine, opiates, methamphetamine) in the past 60 days - Light alcohol use Exclusion Criteria: - Currently using a strain with greater than 1% CBD or less than 18% THC - A University of Colorado student or employee - Heavy tobacco use - Are currently pregnant - In treatment for psychotic disorder, bipolar disorder or schizophrenia |
النتيجة
مقاييس النتائج الأولية
1. Blood Cannabinoid Concentration [Change over 3 time points over 5 days: Baseline (before 5 days of use), Pre-Administration (after 5 days of use but prior to acute use), and Post-Administration (after 5 days of use but 60 minutes after acute use).]
2. Change in Inflammation: Circulating Levels of cytokines (panel of inflammatory markers) [Change over 3 time points over 5 days: Baseline (before 5 days of use), Pre-Administration (after 5 days of use but prior to acute use), and Post-Administration (after 5 days of use but 60 minutes after acute use).]
3. The Drug Effects Questionnaire (DEQ) [Change over 2 time points over 1 hour: Pre-Administration (after 5 days of use but prior to acute self-administration), and Post-Administration (after 5 days of use but 60 minutes after acute self-administration).]
4. The Addiction Research Center Inventory (ARCI) [Change over 2 time points over 1 hour: Pre-Administration (after 5 days of use but prior to acute self-administration), and Post-Administration (after 5 days of use but 60 minutes after acute self-administration).]
5. Profile of Mood States (POMS) [Change over 3 time points over 5 days: Baseline (before 5 days of use), Pre-Administration (after 5 days of use but prior to acute use), and Post-Administration (after 5 days of use but 60 minutes after acute use).]
6. Cognitive Impairment [Change over 3 time points over 5 days: Baseline (before 5 days of use), Pre-Administration (after 5 days of use but prior to acute use), and Post-Administration (after 5 days of use but 60 minutes after acute use).]
