Combined Bioactive Therapy Effects Over Cardiovascular Markers in Statin Treated Patients
الكلمات الدالة
نبذة مختصرة
وصف
From eligible subjects, 70 participants will be recruited for a first visit, when they will give informed consent. Also at the first visit, medical reports will be confirmed by each participant, anthropometric measures will be recorded and blood samples will be collected. After first blood analysis results, participants with stable parameters will be called for a second visit when they will be enrolled in a randomized, placebo-controlled, crossover trial, with 4 treatment periods of 6 weeks each, corresponding to a total of 7 visits. At each visit, blood samples and anthropometric measures will be collected. At the first intervention period, study participants will receive a packaged for the functional or control treatment. Functional treatment packaged will be composed by omega 3 softgels (fish oil), chocolate containing plant sterols and green tea. Control treatment will be composed by soy oil softgels, regular chocolate, and anise tea. Subjects will be advised to consume 3 softgels and 1 chocolate twice a day, after main meals, and to drink two cups of tea per day. After a 6-weeks washout period (third visit), the groups will be switched (crossover) and participants will receive the functional or control treatment for more 6 weeks (fourth visit). After biomarkers evaluation, the subjects with the greatest response to the functional treatment will be selected for additional 6 weeks of functional intervention associated to a reduction of the hypolipidaemic drugs (statin) dosage, which will be prescribed individually and by the evaluation of the responsible physician.
تواريخ
آخر التحقق: | 03/31/2016 |
تم الإرسال لأول مرة: | 04/03/2016 |
تم إرسال التسجيل المقدر: | 04/06/2016 |
أول نشر: | 04/07/2016 |
تم إرسال آخر تحديث: | 04/06/2016 |
آخر تحديث تم نشره: | 04/07/2016 |
تاريخ بدء الدراسة الفعلي: | 04/30/2014 |
تاريخ الإنجاز الأساسي المقدر: | 11/30/2014 |
التاريخ المتوقع لانتهاء الدراسة: | 11/30/2015 |
حالة أو مرض
التدخل / العلاج
Dietary Supplement: Functional treatment
Dietary Supplement: Control treatment
مرحلة
مجموعات الذراع
ذراع | التدخل / العلاج |
---|---|
Experimental: Functional treatment Daily functional treatment consisted of seven fish oil softgels (1.7g EPA+DHA), two dark chocolate truffles containing plant sterol esters and two green tea sachets. | Dietary Supplement: Functional treatment Omega 3 fatty acids, plant sterols and polyphenols |
Placebo Comparator: Control treatment Control treatment consisted of seven soy bean oil softgels, two regular dark chocolate truffles and two anise tea sachets | Dietary Supplement: Control treatment placebo supplements |
معايير الأهلية
الأعمار المؤهلة للدراسة | 40 Years إلى 40 Years |
الأجناس المؤهلة للدراسة | All |
يقبل المتطوعين الأصحاء | نعم |
المعايير | Inclusion Criteria: - The primary selection criteria were current statin (simvastatin or atorvastatin) and hypoglycemic treatment (metformin and/or gliclazide). Exclusion Criteria: - Exclusion criteria were patients who were taking omega 3 fatty acids, plant sterol or green tea supplements; uncontrolled diabetes (HbA1c > 7.5%) or dyslipidemia (LDL-C > 100 mg/dL); pregnant females; and patients who presented any congenital cardiac disorders, uncontrolled endocrine, renal or hepatic disease and excessive alcohol consumption. |
النتيجة
مقاييس النتائج الأولية
1. LDL [after 6 weeks of supplementation]
2. C-reactive protein [after 6 weeks of supplementation]
3. Malondialdehyde [after 6 weeks of supplementation]
مقاييس النتائج الثانوية
1. Omega 3 fatty acids profile [after 6 weeks of supplementation]
2. Cholesterol synthesis and absorption markers [after 6 weeks of supplementation]
3. Antioxidant enzymes activity [after 6 weeks of supplementation]