Health Beneficial Effects of Krill Oil and Lean and Fatty Fish
الكلمات الدالة
نبذة مختصرة
تواريخ
| آخر التحقق: | 10/31/2016 |
| تم الإرسال لأول مرة: | 08/30/2015 |
| تم إرسال التسجيل المقدر: | 10/01/2015 |
| أول نشر: | 10/04/2015 |
| تم إرسال آخر تحديث: | 11/20/2016 |
| آخر تحديث تم نشره: | 11/21/2016 |
| تاريخ بدء الدراسة الفعلي: | 07/31/2015 |
| تاريخ الإنجاز الأساسي المقدر: | 10/31/2016 |
حالة أو مرض
التدخل / العلاج
Dietary Supplement: Krill group
Other: Fish group
Dietary Supplement: Control group
مرحلة
مجموعات الذراع
| ذراع | التدخل / العلاج |
|---|---|
| Experimental: Krill group Krill oil capsules. 4 g/day encapsulated krill oil (Rimfrost Sublime) corresponding to ~900 mg/day EPA + DHA + DPA for 8 weeks. The participants will be instructed to take the capsules with the breakfast and dinner meals. | Dietary Supplement: Krill group The krill group and the control group will be double blinded. The krill oil and placebo capsules will be administered in equal amounts and are of equal size and have the same color. |
| Experimental: Fish group Lean and fatty fish. Three weekly test-meals, containing two meals of fatty fish and one meal of lean fish for 8 weeks corresponding to ~900 mg/day EPA + DHA + DPA. | Other: Fish group The fish group will be open labeled. |
| Placebo Comparator: Control group Placebo capsules. 4 g/day encapsulated high oleic sunflower oil (HOSO) for 8 weeks. The participants will be instructed to take the capsules with the breakfast and dinner meals. | Dietary Supplement: Control group The krill group and the control group will be double blinded. The krill oil and placebo capsules will be administered in equal amounts and are of equal size and have the same color. |
معايير الأهلية
| الأعمار المؤهلة للدراسة | 18 Years إلى 18 Years |
| الأجناس المؤهلة للدراسة | All |
| يقبل المتطوعين الأصحاء | نعم |
| المعايير | Inclusion Criteria: - Healthy volunteers (CRP < 10 mg/L) - Stable weight (± 5 % of body weight) the last three months - BMI 18.5-35 kg/m2 - Fasting triglycerides 1.3-4.0 mmol/L - Willingness to eat fish - Willingness to not take omega-3 or other dietary supplements during the study. Exclusion Criteria: - Pregnancy or lactation - Any chronic disease, including diabetes type 1 or 2. CVD or cancer past 6 months - Elevated thyroid hormones or TSH levels - Elevated total cholesterol (>7.8 mmol/L) or fasting triglycerides (>4.0 mmol/L) - Use of prescription drugs that may affect triglycerides (e.g. diabetes drugs, Cyclosporin A, Orlistat and Sibutramine), except statins if stable dose past 3 months. - Blood pressure > 160/100 mmHg - Hormone treatment (except stable doses the past three months of contraceptives or thyroxine) - Planned weight loss - The use of Vita Proactive or other food items enriched with plant sterols - Excessive alcohol consumption (>40 g/day) - Habitual fish consumption of more than one serving of fatty fish per week |
النتيجة
مقاييس النتائج الأولية
1. Fasting triglycerides [8 weeks]
مقاييس النتائج الثانوية
1. Circulating inflammatory markers [8 weeks]
2. Gene expression of inflammatory markers and genes in lipid metabolism [8 weeks]
3. Plasmamlipids [8 weeks]
4. Lipoprotein subclasses [8 weeks]
5. Plasma fatty acid composition [8 weeks]
6. Blood pressure [8 weeks]
7. Endothelial dysfunction markers [8 weeks]
8. Hemostatic markers [8 weeks]
9. Muscle strength [8 weeks]
10. Whole genome transcriptome analysis in PBMC [8 weeks]
11. Metabolome profile in blood [8 weeks]
12. Metabolome profile in urine [8 weeks]
