Improvement of Metabolic Health After Thylakoid Supplementation
الكلمات الدالة
نبذة مختصرة
وصف
Twenty healthy, non-vegetarian, non-smoking Caucasian men were included in the study. Inclusion criteria: men aged 40 to 70 years with a BMI of 25 to 35. Exclusion criteria: Metabolic disturbances, bariatric surgery, recent diet, food allergies or treatment with antibiotics. The study protocol was approved by the Ethical Committee of Lund University, Sweden (#2006/361).
The trial consisted of three periods: 1) diet-restriction period (one month) 2) stabilizing period (one month) 3) diet-restriction period with supplementation of thylakoids or placebo (one month). The two weight-losing periods included strict diet recommendation with -30 energy % (E%), and macronutrient composition: 55-65 E% carbohydrates, 10-15 E% protein and 25-35 E% fat. Sixty minutes of low intensive exercise per day was also required.
During the stabilizing month participants were instructed to eat a healthy diet to be able to keep their achieved weight-loss.
Day 0, 28, 56 and 84 the participants arrived after 12-hour fasting for blood sampling and anthropometric measurements. The blood samples were analyzed for plasma-glucose, insulin, HbA1c, inflammation markers, cholecystokinin, ghrelin, total cholesterol, LDL-cholesterol, HDL-cholesterol, and triacylglycerol.
تواريخ
| آخر التحقق: | 01/31/2016 |
| تم الإرسال لأول مرة: | 02/09/2016 |
| تم إرسال التسجيل المقدر: | 02/15/2016 |
| أول نشر: | 02/21/2016 |
| تم إرسال آخر تحديث: | 02/15/2016 |
| آخر تحديث تم نشره: | 02/21/2016 |
| تاريخ بدء الدراسة الفعلي: | 12/31/2009 |
| تاريخ الإنجاز الأساسي المقدر: | 04/30/2010 |
| التاريخ المتوقع لانتهاء الدراسة: | 12/31/2015 |
حالة أو مرض
التدخل / العلاج
Dietary Supplement: Thylakoid group
Other: Control group
مرحلة
مجموعات الذراع
| ذراع | التدخل / العلاج |
|---|---|
| Placebo Comparator: Control group Control group subjects received the same diet restriction intervention as treatment group. However, their food products did not contain any active component. | Other: Control group |
| Active Comparator: Thylakoid group Thylakoid group subjects received the same diet restriction intervention as the control group. However, their food products did contain an active component in the form of thylakoid powder. | Dietary Supplement: Thylakoid group |
معايير الأهلية
| الأعمار المؤهلة للدراسة | 40 Years إلى 40 Years |
| الأجناس المؤهلة للدراسة | Male |
| يقبل المتطوعين الأصحاء | نعم |
| المعايير | Inclusion Criteria: - Healthy, overweight, non-vegetarian, non-smoking Exclusion Criteria: - Medication for metabolic disturbances, previous bariatric surgery, diabetes, had been on diet or treated with antibiotics during last 3 months, food-allergies |
النتيجة
مقاييس النتائج الأولية
1. Body weight [3 months]
مقاييس النتائج الثانوية
1. Waist circumference [3 months]
2. Blood lipids [3 months]
3. P-glucose and p-insulin [3 months]
4. Inflammatory markers [3 months]
5. Appetite regulating hormones [3 months]
