Intervention With n3 LC-PUFA-supplemented Yogurt
الكلمات الدالة
نبذة مختصرة
وصف
Fifty three mildly hypertriacylglycerolemic subjects (TAG ≥ 150 mg/dL (1.7 mmol/L)) participated on the placebo-controlled, double-blind, parallel designed study.
The subjects consumed placebo yoghurt (1), or n3 LC-PUFA-enriched yoghurt (0.8 g n3 LC-PUFA/d (2), 3 g n3 LC-PUFA/d (3)) for 10 weeks.
Blood samples were taken at the beginning and at the end of the period.
Parameters:
- Blood lipids (total cholesterol, HDL, LDL, triacylglycerols)
- Fatty acid distribution of plasma lipids (PL) and erythrocyte membranes (EM)
- Concentrations of eicosanoids (PGs, HETEs)
- Production of ex vivo stimulated cytokines by T cells
- SNPs in the CD36 genotype
تواريخ
| آخر التحقق: | 02/29/2012 |
| تم الإرسال لأول مرة: | 11/15/2010 |
| تم إرسال التسجيل المقدر: | 11/17/2010 |
| أول نشر: | 11/18/2010 |
| تم إرسال آخر تحديث: | 03/05/2012 |
| آخر تحديث تم نشره: | 03/06/2012 |
| تاريخ بدء الدراسة الفعلي: | 01/31/2009 |
| تاريخ الإنجاز الأساسي المقدر: | 03/31/2009 |
| التاريخ المتوقع لانتهاء الدراسة: | 03/31/2009 |
حالة أو مرض
التدخل / العلاج
Dietary Supplement: n3 long chain polyunsaturated fatty acids
مرحلة
معايير الأهلية
| الأعمار المؤهلة للدراسة | 25 Years إلى 25 Years |
| الأجناس المؤهلة للدراسة | All |
| يقبل المتطوعين الأصحاء | نعم |
| المعايير | Inclusion Criteria: - hypertriacylglycerolemic subjects (TAG: ≥ 150 mg/dl (1.7 mmol/l)) Exclusion Criteria: - patients receiving blood-diluting and lipid-lowering medications or glucocorticoids - patients suffering from gastrointestinal or metabolic diseases (e.g., diabetes mellitus, hyper- and hypothyroidism) and hypercholesteremic patients with familial previous impacts - patients taking dietary supplements (e.g., fish oil capsules, vitamin E) or having either known allergies or foodstuff indigestibility - further exclusion criteria: smoking, high sportive activity or daily alcohol intake |
النتيجة
مقاييس النتائج الأولية
1. Blood lipids (total cholesterol, HDL, LDL, triacylglycerols) [change from baseline after 10 weeks]
مقاييس النتائج الثانوية
1. fatty acid distribution in plasma lipids and erythrocyte membranes, eicosanoids in plasma, production of ex vivo stimulated cytokines by T cells, SNPs on CD36 genotype [change from baseline after 10 weeks]
