The Effect of Oily Fish and Poultry on Children's Cardiometabolic Health and Cognitive Function
الكلمات الدالة
نبذة مختصرة
وصف
The FiSK Junior study compares the effects of consuming oily fish versus poultry (control) in healthy 8-9 year-old Danish children. The children will be randomized to consume approximately 300 g/week of either oily fish or poultry for 12 weeks. Measurements and biological sampling will be performed at baseline and at the end of the intervention.
The main objective of the study is to investigate the effect on cardiovascular risk markers, primarily blood pressure and plasma triacylglycerol. Moreover, the effects on cognitive function, behaviour, emotions and physiological stress response will be assessed. In addition, change in n-3 long chain polyunsaturated fatty acid status (compliance), anthropometry, body composition, vitamin D status, inflammatory markers, growth markers, physical activity and diet will be measured. Outcomes will be analysed with focus on potential gender- and genotype-specific effects.
تواريخ
| آخر التحقق: | 05/31/2017 |
| تم الإرسال لأول مرة: | 06/05/2016 |
| تم إرسال التسجيل المقدر: | 06/16/2016 |
| أول نشر: | 06/21/2016 |
| تم إرسال آخر تحديث: | 06/25/2017 |
| آخر تحديث تم نشره: | 06/26/2017 |
| تاريخ بدء الدراسة الفعلي: | 07/31/2016 |
| تاريخ الإنجاز الأساسي المقدر: | 06/22/2017 |
| التاريخ المتوقع لانتهاء الدراسة: | 06/22/2017 |
حالة أو مرض
التدخل / العلاج
Dietary Supplement: Oily fish
Dietary Supplement: Poultry (control)
مرحلة
مجموعات الذراع
| ذراع | التدخل / العلاج |
|---|---|
| Experimental: Oily fish | Dietary Supplement: Oily fish A selection of oily fish, including salmon, herring and mackerel, provided for dinner and lunch |
| Experimental: Poultry (control) | Dietary Supplement: Poultry (control) A selection of poultry, mainly chicken, provided for dinner and lunch |
معايير الأهلية
| الأعمار المؤهلة للدراسة | 8 Years إلى 8 Years |
| الأجناس المؤهلة للدراسة | All |
| يقبل المتطوعين الأصحاء | نعم |
| المعايير | Inclusion Criteria: Children must: - Be 8 - 9 years of age at the start of the intervention - Be healthy - Like oily fish and chicken - Be willing to be randomized to eat fish or chicken - Not consume oily fish more than once per week 3 months prior to intervention start - Not consume fish oil 3 months prior to intervention start - Speak Danish in order to understand the study procedures Moreover: - Parents must read and speak Danish, in order to be properly informed about the study procedures - The child must live in a household with ≤5 persons Exclusion Criteria: - Serious chronic illnesses and diseases that may interfere with study outcomes - Diagnosed Attention Deficit Hyperactivity Disorder (ADHD) or other psychiatric illness - Intake of medication that may affect study outcomes - Concomitant participation in other studies involving dietary supplements or blood sampling - Living in a household with another participating child |
النتيجة
مقاييس النتائج الأولية
1. Blood pressure [At 12 weeks]
2. Serum triacylglycerol concentration [At 12 weeks]
مقاييس النتائج الثانوية
1. Serum LDL cholesterol [At 12 weeks]
2. Serum HDL cholesterol [At 12 weeks]
3. Serum insulin [At 12 weeks]
4. Plasma glucose [At 12 weeks]
5. Blood glycosylated haemoglobin (HbA1c) [At 12 weeks]
6. Heart rate [At 12 weeks]
7. BMI z-score [At 12 weeks]
8. Waist circumference [At 12 weeks]
9. Fat mass index by bioimpedance [At 12 weeks]
10. Cognitive function measured by the Cambridge Neuropsychological Test Automated Battery [At 12 weeks]
11. Response inhibition measured by Flanker test [At 12 weeks]
12. Selective attention capacity measured by Stroop Test [At 12 weeks]
13. Attention measured by the D2 Test of Attention [At 12 weeks]
14. Saliva cortisol after cold-pressor task [At 12 weeks]
15. Hair cortisol [At 12 weeks]
16. Compliance measured by content of n-3 long-chain polyunsaturated fatty acids in red blood cells [At 12 weeks]
تدابير النتائج الأخرى
1. Behaviour measured by the Strengths and Difficulties Questionnaire [At 12 weeks]
2. Behaviour measured by the Behavior Rating Inventory of Executive Function Questionnaire [At 12 weeks]
3. Serum insulin-like growth factor-1 [At 12 weeks]
4. Serum C-reactive protein [At 12 weeks]
5. Serum 25-hydroxy-vitamin D [At 12 weeks]
6. Physical activity [At 12 weeks]
