The Effects of Rhus Coriaria L. on Serum Lipid Levels of Patients With Hyperlipidemia
الكلمات الدالة
نبذة مختصرة
وصف
Rhus (Somagh) is found in temperate and tropical regions worldwide, often growing in areas of marginal agricultural capacity. Rhus is used as an herbal remedy in traditional medicine because of its assumed analgesic, antidiarrhetic, antiseptic, anorexic and antihypergylcemic properties. The fruits of Rhus contain flavonols, phenolic acids, hydrolysable tannins, anthocyans and organic acids such as malice, citric and tartaric acids. Some studies have shown that polyphenols could have beneficial effects on cardiovascular disease and cancer and could be regarded as bioactive compounds with a high potential health-promoting capacity. Phenolic compounds inhibit lipid peroxidation, scavenge the superoxide anion and hydroxyl radical, and enhance the activities of detoxifying enzymes.Moreover, the hypocholesterolemic action of dietary polyphenols has been reported. The hypocholesterolemic effect of Rhus fruit powder and its components have been reported previously in rabbits and mice.
تواريخ
آخر التحقق: | 05/31/2016 |
تم الإرسال لأول مرة: | 11/09/2014 |
تم إرسال التسجيل المقدر: | 11/16/2014 |
أول نشر: | 11/19/2014 |
تم إرسال آخر تحديث: | 06/03/2016 |
آخر تحديث تم نشره: | 06/06/2016 |
تاريخ بدء الدراسة الفعلي: | 11/30/2014 |
تاريخ الإنجاز الأساسي المقدر: | 03/31/2015 |
التاريخ المتوقع لانتهاء الدراسة: | 04/30/2015 |
حالة أو مرض
التدخل / العلاج
Drug: Rhus
Drug: Placebo
مرحلة
مجموعات الذراع
ذراع | التدخل / العلاج |
---|---|
Experimental: Rhus 500 mg of Rhus Coriaria L. (Rhus) powder in capsule: 1 capsule twice daily for 6 weeks | Drug: Rhus 500 mg of Rhus Coriaria L. (Rhus) powder in capsule: 1 capsule twice daily for 6 weeks |
Placebo Comparator: Placebo Placebo capsule: 1 capsule twice daily for 6 weeks | Drug: Placebo Placebo capsule: 1 capsule twice daily for 6 weeks |
معايير الأهلية
الأعمار المؤهلة للدراسة | 20 Years إلى 20 Years |
الأجناس المؤهلة للدراسة | All |
يقبل المتطوعين الأصحاء | نعم |
المعايير | Inclusion Criteria: - Age: 20-65 years - Serum triglyceride >150mg/dl AND/OR total cholesterol >= 240mg/dl Exclusion Criteria: - Serum triglyceride > 500 mg/dl - Serum LDL-cholesterol at level which need drug treatment according to the patient risk categories (NCEP-ATP III) - Diabetes mellitus - Hypo. or hyperthyroidism - Any systemic illnesses e.g. liver cirrhosis, acute or chronic renal failure, heart failure - Use of drugs: OCPs, lipid lowering agents, thiazides - Pregnancy - Alcoholism - History of allergic reaction to Somagh |
النتيجة
مقاييس النتائج الأولية
1. Serum total cholesterol level [6 weeks]
2. Serum triglyceride level [6 weeks]
3. Serum HDL-cholesterol level [6 weeks]
مقاييس النتائج الثانوية
1. Serum LDL-cholesterol level [6 weeks]
2. Fasting Blood Sugar (FBS) [6 weeks]
3. Serum creatinin level [6 weeks]
4. Serum ALT level [6 weeks]
5. Serum AST level [6 weeks]
6. Serum alkaline phosphatase level [6 weeks]
7. Number of patients with adverse events [10 weeks]