Bioavailability and Absorption Kinetics of Phenolic Compounds and Specific Vitamins
الكلمات الدالة
نبذة مختصرة
وصف
Phytonutrients are regarded to play an important role in many health-related issues like:
- Improvement of redox balance
- Anti-inflammatory effects
- Prevention of chronic diseases like CVD, stroke, diabetes II, Alzheimer´s, AMD, and certain forms of cancer
- Beneficial effects on human´s microbiome Therefore it is of scientific interest whether this product provides absorbable phytonutrients/phenolics and vitamins to support mechanistic explanations for the beneficial outcomes observed in the past after intake of Juice Plus+®.
GOAL To identify absorption kinetics and bioavailability of phenolic compounds and specific vitamins from encapsulated Juice Plus+® powder
MERITS
- This study would reveal knowledge whether and to which extent specific vitamins and phenolic compounds are absorbed, including absorption kinetics/metabolism.
- Data of this study may provide support for mechanistic arguments on the beneficial clinical outcomes observed and published in the past.
ENDPOINTS
- Absorption kinetics of phenolic compounds in plasma
- Bioavailability of vitamins C, E, and carotenoids into plasma
Absorption kinetics of phytonutrients:
- Open-, one-arm study, absorption kinetics over 10 hours
- 5 blood sample collections: baseline (= 0); 1hr, 2hrs, 5hrs and 10 hours after intake of 3 capsules
- Wash-out of all food supplements and dietetic foodstuff: 2 weeks
- Wash-out of phytonutrients: 48 hours before baseline sampling, accomplished via a phytonutrient-poor diet.
Bioavailability of vitamins C, E, A and carotenoids:
- Open-, one-arm study over 8 weeks
- 2 blood sample collections: at baseline (2 weeks after the phenolics experiment) and after 8-weeks
- Wash-out of all food supplements and dietetic foodstuff: 4 weeks, 2 weeks before the phenolics experiment + another 2 weeks Subjects: 20 healthy subjects from Graz region, meeting all inclusion criterions (see underneath).
تواريخ
آخر التحقق: | 06/30/2017 |
تم الإرسال لأول مرة: | 10/21/2015 |
تم إرسال التسجيل المقدر: | 10/22/2015 |
أول نشر: | 10/26/2015 |
تم إرسال آخر تحديث: | 07/28/2017 |
آخر تحديث تم نشره: | 07/31/2017 |
تاريخ بدء الدراسة الفعلي: | 09/30/2015 |
تاريخ الإنجاز الأساسي المقدر: | 05/31/2017 |
التاريخ المتوقع لانتهاء الدراسة: | 06/30/2017 |
حالة أو مرض
التدخل / العلاج
Dietary Supplement: Juice Plus+(R)
مرحلة
مجموعات الذراع
ذراع | التدخل / العلاج |
---|---|
Experimental: Juice Plus+(R) Check of phenolic absorption between baseline and after 8wks of intake before-after comparison | Dietary Supplement: Juice Plus+(R) before-after comparison of plasma phenolics |
معايير الأهلية
الأعمار المؤهلة للدراسة | 20 Years إلى 20 Years |
الأجناس المؤهلة للدراسة | All |
يقبل المتطوعين الأصحاء | نعم |
المعايير | Inclusion Criteria: - 20 healthy men and women, 20-50 years old; - non-smokers; - BMI >20 und <30 kg/m2; - no medication; - premenopausal; - normal dietary habits (no specific diets, meals, food components etc.); - adherence to wash-out period. Exclusion Criteria: - all people not meeting the inclusion criterions; - diet: subjects consuming >4 servings of fruits and vegetables per day; - subjects with any kind of food allergy or histamine intolerance; - highly trained subjects (> 5 training units/week); - women with menstrual dysfunctions; - pregnancy - alcoholics. |
النتيجة
مقاييس النتائج الأولية
1. Absorption kinetics of phenolic acids after 1, 2, 5 and 10 hours, measured via HPLC, evaluated by repeated measures ANOVA, and assessed via SPSS 19.0. [1 year]
مقاييس النتائج الثانوية
1. Absorption of ß-carotene after 8 weeks of supplementation, measured via HPLC, evaluated by paired t-test, and assessed via SPSS 19.0 [1 year]