Disposition of Dietary Polyphenols and Methylxanthines in Mammary Tissues From Breast Cancer Patients
الكلمات الدالة
نبذة مختصرة
وصف
The objective of this exploratory trial is to determine the disposition and characterise the metabolic profiling of dietary polyphenols in normal and malignant glandular breast tissues from newly diagnosed breast cancer patients.
The patients consumed a polyphenol-rich dietary supplement containing 37 different phenolics and 2 methylxanthines (theobromine and caffeine) from the diagnosis to the surgery. The metabolic profiling was characterized in normal and malignant breast tissues as well as plasma and urine using UPLC-ESI-QTOF-MS/MS.
تواريخ
| آخر التحقق: | 07/31/2019 |
| تم الإرسال لأول مرة: | 03/14/2018 |
| تم إرسال التسجيل المقدر: | 03/21/2018 |
| أول نشر: | 03/28/2018 |
| تم إرسال آخر تحديث: | 03/11/2020 |
| آخر تحديث تم نشره: | 03/12/2020 |
| تاريخ بدء الدراسة الفعلي: | 05/31/2017 |
| تاريخ الإنجاز الأساسي المقدر: | 11/30/2018 |
| التاريخ المتوقع لانتهاء الدراسة: | 12/30/2019 |
حالة أو مرض
التدخل / العلاج
Dietary Supplement: Polyphenol group
مرحلة
مجموعات الذراع
| ذراع | التدخل / العلاج |
|---|---|
| Experimental: Polyphenol group Patients consumed a polyphenol-rich dietary supplement (commercial lemon, orange, pomegranate, olive, grape, cocoa, curcuma and broccoli extracts), mainly rich in simple phenolics such as hydroxytyrosol and the polyphenols procyanidins, hesperidin, eriocitrin, curcumin, resveratrol, punicalagin and ellagic acid. Cocoa extract also contains the methylxanthines theobromine and caffeine. | Dietary Supplement: Polyphenol group Patients consume 3 capsules/day (474 mg phenolics/day) from the biopsy-confirmed breast cancer diagnosis to the surgery |
| No Intervention: Control group Participating patients did not consume the supplement but provided biological samples to the trial |
معايير الأهلية
| الأعمار المؤهلة للدراسة | 18 Years إلى 18 Years |
| الأجناس المؤهلة للدراسة | All |
| يقبل المتطوعين الأصحاء | نعم |
| المعايير | Inclusion Criteria: - Eligible patients are those over 18 years with a newly biopsy-confirmed breast cancer, programmed surgery at least 3 days after the recruitment and no neoadjuvant treatment. Exclusion Criteria: - Suspected intolerance to any component of fruits or vegetables. - Neoadjuvant chemo- or radiotherapy. - Urgent surgery (less than 3 days after the recruitment). - Patient under 18 years. - Patient with breast adenoma. |
النتيجة
مقاييس النتائج الأولية
1. Quantification of dietary polyphenols and methylxanthines in breast tissues [1-24 months]
مقاييس النتائج الثانوية
1. Quantification of dietary polyphenols and methylxanthines in plasma and urine [8-24 months]
