Guanidinoacetic Acid Loading for Chronic Fatigue Syndrome
الكلمات الدالة
نبذة مختصرة
وصف
A variety of dietary interventions have been used in the management of CFS, yet no therapeutic modality demonstrated overall positive results in terms of effectiveness (Whiting et al. 2001). Previous studies have evaluated the effects of essential fatty acids, vitamins, minerals and/or enzymes, with findings do not support the use of a broad-spectrum nutritional supplement in treating CFS‐related symptoms (Brouwers et al. 2002). Considering the fact that patients with CFS have lower levels of high-energy compounds (e.g. phosphocreatine, adenosine triphosphate) (Block et al. 1998), effective dietary treatment of CFS should be focused on providing compounds that facilitates cellular bioenergetics. Besides other candidate agents, guanidinoacetic acid (GAA) could be of particular interest since it occurs naturally in the human body and acts as an immediate precursor of creatine (Wyss and Kaddurah-Daouk, 2000). Due to its low cost and high bioavailability (Baker 2009), if proven effective dietary GAA may be suitable for use in broad CFS population.
تواريخ
آخر التحقق: | 12/31/2016 |
تم الإرسال لأول مرة: | 08/04/2014 |
تم إرسال التسجيل المقدر: | 08/06/2014 |
أول نشر: | 08/10/2014 |
تم إرسال آخر تحديث: | 01/29/2017 |
آخر تحديث تم نشره: | 01/31/2017 |
تاريخ بدء الدراسة الفعلي: | 07/31/2014 |
تاريخ الإنجاز الأساسي المقدر: | 05/31/2015 |
التاريخ المتوقع لانتهاء الدراسة: | 06/30/2015 |
حالة أو مرض
التدخل / العلاج
Dietary Supplement: Guanidinoacetic acid
Other: Placebo
مرحلة
مجموعات الذراع
ذراع | التدخل / العلاج |
---|---|
Experimental: Guanidinoacetic acid Supplementation with dietary guanidinoacetic acid | Dietary Supplement: Guanidinoacetic acid Dietary supplement |
Placebo Comparator: Placebo Supplementation with cellulose | Other: Placebo Placebo |
معايير الأهلية
الأعمار المؤهلة للدراسة | 18 Years إلى 18 Years |
الأجناس المؤهلة للدراسة | All |
يقبل المتطوعين الأصحاء | نعم |
المعايير | Inclusion Criteria: - Adults who fulfilled the 1994 CDC criteria for CFS - Older than 18 years of age will be candidates for inclusion in the study. Exclusion Criteria: - Psychiatric comorbidity - Use of any dietary supplement within 4-weeks prior to the study commencing - Pregnant |
النتيجة
مقاييس النتائج الأولية
1. Change in the Multidimensional Fatigue Inventory (MFI) score [Baseline and afetr 3 months]
مقاييس النتائج الثانوية
1. Pain in the locomotive apparatus [Baseline and after 3 months]
تدابير النتائج الأخرى
1. Health-related quality of life [Baseline and after 3 months]
2. Daily physical activity [Baseline and after 3 months]
3. Muscular strength [Baseline and after 3 months]
4. Serum creatine [Baseline and after 3 months]
5. Side-effects prevalence [During 3 months of intervention]