Oral β-Alanine Supplementation in Patients With COPD
Açar sözlər
Mücərrəd
Tarixlər
| Son Doğrulandı: | 01/31/2019 |
| İlk təqdim: | 05/08/2016 |
| Təxmini qeydiyyat təqdim edildi: | 05/10/2016 |
| İlk Göndərmə: | 05/11/2016 |
| Son Yeniləmə Göndərildi: | 02/20/2019 |
| Son Yeniləmə Göndərildi: | 02/21/2019 |
| Həqiqi Təhsilin Başlama Tarixi: | 04/30/2016 |
| Təxmini İlkin Tamamlanma Tarixi: | 01/31/2019 |
| Təxmini İşin Tamamlanma Tarixi: | 01/31/2019 |
Vəziyyət və ya xəstəlik
Müdaxilə / müalicə
Dietary Supplement: COPD (beta-alanine)
Dietary Supplement: COPD (placebo)
Other: Healthy controls
Faza
Qol Qrupları
| Qol | Müdaxilə / müalicə |
|---|---|
| Active Comparator: COPD (beta-alanine) | Dietary Supplement: COPD (beta-alanine) Patients receive beta-alanine |
| Placebo Comparator: COPD (placebo) | Dietary Supplement: COPD (placebo) Patients receive placebo |
| Other: Healthy controls | Other: Healthy controls Healthy controls will be assessed to compare baseline muscle carnosine levels |
Uyğunluq Kriteriyaları
| Təhsil üçün uyğun yaşlar | 40 Years Üçün 40 Years |
| Təhsilə Uyğun Cinslər | All |
| Sağlam Könüllüləri qəbul edir | Bəli |
| Kriteriyalar | Inclusion Criteria: - COPD: diagnosis of moderate to very severe COPD according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines - Healthy controls: forced expiratory volume at one second/forced vital capacity (FEV1/FVC) > 0.7, matched for age and gender Exclusion Criteria: - The presence of known instable cardiac disease - neurological disease and/or musculoskeletal disease that preclude safe participation in an exercise test - a history of drugs/alcohol abuse - vegetarianism - inability to understand the Flemish language. COPD-specific exclusion criteria: - COPD exacerbation and/or hospitalization in the last 6 weeks - participation in pulmonary rehabilitation in the previous 12 months. |
Nəticə
İlkin nəticə tədbirləri
1. muscle carnosine [change from baseline to 12 weeks]
2. maximal exercise capacity [change from baseline to 12 weeks]
3. submaximal exercise capacity [change from baseline to 12 weeks]
İkincili Nəticə Tədbirləri
1. Functional exercise test 1 [change from baseline to 12 weeks]
2. Functional exercise test 2 [change from baseline to 12 weeks]
3. Muscle function quadriceps [change from baseline to 12 weeks]
4. Respiratory muscle function [change from baseline to 12 weeks]
5. Muscle function hand grip [change from baseline to 12 weeks]
6. Muscle characteristics [change from baseline to 12 weeks]
7. Blood parameters submaximal exercise test [change from baseline to 12 weeks]
8. Blood parameters fasted state [change from baseline to 12 weeks]
9. Blood parameters maximal exercise test [change from baseline to 12 weeks]
10. Comorbidities [change from baseline to 12 weeks]
11. Comorbidities: ankle-brachial pressure index [change from baseline to 12 weeks]
12. Comorbidities blood pressure [change from baseline to 12 weeks]
13. Comorbidities body composition 1 [change from baseline to 12 weeks]
14. Comorbidities body composition 2 [change from baseline to 12 weeks]
15. Quality of life: anxiety and depression [change from baseline to 12 weeks]
16. Quality of life: fatigue [change from baseline to 12 weeks]
17. Quality of life: dyspnea [change from baseline to 12 weeks]
18. Quality of life: general [change from baseline to 12 weeks]
19. Quality of life: COPD [change from baseline to 12 weeks]
20. Physical activity: accelerometer [change from baseline to 12 weeks]
21. Physical activity: questionnaire 1 [change from baseline to 12 weeks]
22. Physical activity: questionnaire 2 [change from baseline to 12 weeks]
23. Lung function [change from baseline to 12 weeks]
24. Heart function [change from baseline to 12 weeks]
