Prevention of Cancer Development and Progression
Açar sözlər
Mücərrəd
Təsvir
Cancer is considered to be the leading cause of death among non-infectious diseases and the most important obstacle to increase life expectancy for every country in the 21st century. However, even if various interventions such as embolization chemotherapy, systemic chemotherapy, radiofrequency ablation, and targeted therapy are widely used in clinical practice, the improvement of patients' survival is still limited. Our previous study found that arginine hydrochloride could significantly promote the apoptosis of liver cancer cells, and inhibit the progression of HCC by prompting the urea cycle. Therefore, our research group has carried out this study to evaluate the efficacy of arginine in preventing cancers.
Tarixlər
| Son Doğrulandı: | 04/30/2019 |
| İlk təqdim: | 05/04/2019 |
| Təxmini qeydiyyat təqdim edildi: | 05/04/2019 |
| İlk Göndərmə: | 05/06/2019 |
| Son Yeniləmə Göndərildi: | 05/04/2019 |
| Son Yeniləmə Göndərildi: | 05/06/2019 |
| Həqiqi Təhsilin Başlama Tarixi: | 05/09/2019 |
| Təxmini İlkin Tamamlanma Tarixi: | 08/09/2024 |
| Təxmini İşin Tamamlanma Tarixi: | 05/09/2025 |
Vəziyyət və ya xəstəlik
Müdaxilə / müalicə
Drug: Intervention
Faza
Qol Qrupları
| Qol | Müdaxilə / müalicə |
|---|---|
| No Intervention: Observation Subjects only accept the routine treatment for underlying diseases. | |
| Experimental: Intervention Based on the routine treatment for underlying diseases, subjects were administrated by arginine. | Drug: Intervention Arginine hydrochloride injection 5g/dose; 40g/d; ivgtt; sustained medication for 24 days; drug withdrawal for 4 days. Treatment is continued until the levels of tumor marker dropped to normal |
Uyğunluq Kriteriyaları
| Təhsil üçün uyğun yaşlar | 40 Years Üçün 40 Years |
| Təhsilə Uyğun Cinslər | All |
| Sağlam Könüllüləri qəbul edir | Bəli |
| Kriteriyalar | Inclusion Criteria: - 1. Ages 40-75 years 2. 2 ULN of tumor markers (CEA, AFP, ca-125, ca19-9, NSE, HCG and cyfra21-1) 3. No space-occupying lesions were found by the current imaging examination 4. The major organ function is normal that is meeting the following standards: Blood routine examination: (No blood transfusion, no G-CSF and no medication were corrected within 14 days before screening) a.HB≥80g/L； b.ANC≥1.5×109/L；c.PLT≥50×109/L; Biochemical examination: (ALB was not transfused within 14 days before screening) a. ALB ≥29 g/L； b.ALT and AST<5ULN；c. TBIL ≤3ULN；d.creatinine ≤1.5ULN( albumin and bilirubin, two indicators of Child-Pugh liver function class, can only have one for 2 points) 5. For women of childbearing age, the results of serum/urine pregnancy tests must be negative within 7 days before initiation of treatment. All men and women who participate in the study have to take reliable contraceptive measures within the trial and eight weeks after the trial is completed 6. volunteers must signed informed consent. Exclusion Criteria: - 1. patients suffering from any malignant tumors in the past (within 5 years) or at the same time; excluding cured basal cell carcinoma and carcinoma in situs of cervix 2. Patients who are undergoing transplantation or have a history of organ transplantation 3. Patients with an allergic history of arginine hydrochloride 4. The blood pressure cannot be reduced to the normal range by the antihypertensive drug treatment in patients with hypertension(systolic pressure＞140 mmHg, diastolic pressure＞90 mmHg) 5. Patients with myocardial ischemia or myocardial infarction over grade II or a poorly controlled arrhythmia (including QTc interval: men ≥450 ms; women ≥470 ms) 6.Cardiac functional insufficiency of grade III to IV according to NYHA standard; echocardiography: LVEF＜50% 7. Patients with severe organ damage and less than 3 years expected survival time 8. Pregnant or lactating women; fertile patients who are unwilling or unable to adopt effective contraceptives 9. Patients with mental sickness or the history of psychotropic drug abuse 10. Patients with severe infection (unable to control the infection effectively) 11. The researchers believe that any other factors unsuitable for entering into the study. |
Nəticə
İlkin nəticə tədbirləri
1. Incidence [60 months]
İkincili Nəticə Tədbirləri
1. tumor markers [60 months]
2. Chinese Quality of Life Questionnaire - EORTC QLQ-C30 score [60 months]
