Calcium, Protein and Gut Hormones
Açar sözlər
Mücərrəd
Təsvir
Participants will be asked to arrive to the laboratory between 08:00 and 10:00 am after not eating for between 8-14 hours i.e. in a fasted state (water intake is permitted and encouraged). Participants will then be given one of three test drinks: 1) calcium citrate (1000 mg); 2) milk mineral supplement (equating to 1000 mg calcium); or 3) milk mineral supplement (equating to 1000 mg calcium) plus whey protein hydrolysate (50 g). Each of these drinks will also contain 500 mL of water and artificial sweetener (80 mg sucralose).
Blood samples will be taken before, and at 15, 30, 45, 60, 90 and 120 minutes after ingestion of the test drink to determine the concentrations of gut hormones (GIP, GLP-1 and PYY) circulating in the bloodstream. We will also ask participants to complete an appetite questionnaire at baseline and every 30 minutes after ingestion of the test drink to assess their appetite sensations. After the 120-minute time point, we will remove the cannula and the trial day will be complete.
Tarixlər
| Son Doğrulandı: | 07/31/2018 |
| İlk təqdim: | 07/24/2017 |
| Təxmini qeydiyyat təqdim edildi: | 07/24/2017 |
| İlk Göndərmə: | 07/26/2017 |
| Son Yeniləmə Göndərildi: | 08/25/2018 |
| Son Yeniləmə Göndərildi: | 08/27/2018 |
| Həqiqi Təhsilin Başlama Tarixi: | 04/30/2017 |
| Təxmini İlkin Tamamlanma Tarixi: | 12/04/2017 |
| Təxmini İşin Tamamlanma Tarixi: | 01/30/2018 |
Vəziyyət və ya xəstəlik
Müdaxilə / müalicə
Dietary Supplement: Calcium Citrate
Dietary Supplement: Milk Mineral Supplement
Dietary Supplement: Milk mineral supplement plus Whey Protein Hydrolysate
Faza
Qol Qrupları
| Qol | Müdaxilə / müalicə |
|---|---|
| Placebo Comparator: Calcium Citrate Calcium citrate (1000 mg calcium) will be consumed by participants in the morning between 8-10 am after 8-14 h fasting. Blood samples, appetite scales and expired breath samples will be taken in a regular intervals for 2 h after ingestion. | Dietary Supplement: Calcium Citrate 1000 mg calcium as calcium citrate |
| Active Comparator: Milk Mineral Supplement Milk mineral supplement (equating to 1000 mg calcium) will be consumed by participants in the morning between 8-10 am after 8-14 h fasting. Blood samples, appetite scales and expired breath samples will be taken in a regular intervals for 2 h after ingestion. | |
| Experimental: Milk mineral supplement plus Whey Protein Hydrolysate Milk mineral supplement (equating to 1000 mg calcium) plus whey protein hydrolysate (50 g) will be consumed by participants in the morning between 8-10 am after 8-14 h fasting. Blood samples, appetite scales and expired breath samples will be taken in a regular intervals for 2 h after ingestion. | Dietary Supplement: Milk mineral supplement plus Whey Protein Hydrolysate 50 g whey protein hydrolysate |
Uyğunluq Kriteriyaları
| Təhsil üçün uyğun yaşlar | 18 Years Üçün 18 Years |
| Təhsilə Uyğun Cinslər | All |
| Sağlam Könüllüləri qəbul edir | Bəli |
| Kriteriyalar | Inclusion Criteria: - Healthy men and women age between 18-65 yrs. - Able to consume provided supplement. - Weigh stable for the past 3 month (no change within 3%). Exclusion Criteria: - Any previous or current metabolic, cardio-pulmonary or musculoskeletal disease - Not between the ages of 18-65 years - A body mass index below 18.5 kg/m2 or above 30 kg/m2 (body mass (kg) divided by your height (m) squared) - Taking medications that may influence your metabolism - Plans to change your lifestyle (diet and/or physical activity) during the study period - Not willing to refrain from alcohol containing drinks or unaccustomed exercise one day before the laboratory sessions. - Current smoker |
Nəticə
İlkin nəticə tədbirləri
1. Postprandial plasma GLP-1 area under the curve (mmol/L x 120 min). [120 min]
İkincili Nəticə Tədbirləri
1. Postprandial plasma GIP area under the curve (mmol/L x 120 min) [120 min]
2. Postprandial plasma PYY area under the curve (mmol/L x 120 min) [120 min]
3. Subjective ratings of appetite (au) [120 min]
4. Energy metabolism (carbohydrate and fat oxidation) [120 min]
5. Postprandial plasma glucose [120 min]
6. Blood pressure [120 min]
