Dental Malocclusion and Craniofacial Development in OI

Yalnız qeydiyyatdan keçmiş istifadəçilər məqalələri tərcümə edə bilərlər

Giriş / Qeydiyyatdan keçin

Bağlantı panoya saxlanılır

StatusAktiv, işə qəbul deyil

Sponsorlar

Baylor College of Medicine

Əməkdaşlar

Shriners Hospitals for Children

Hospital for Special Surgery, New York

University of Nebraska

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

Children's National Research Institute

University of California, Los Angeles

Oregon Health and Science University

KLINIK SINAQ: NCT02934451

BioSeek: nct02934451

Açar sözlər

Mücərrəd

Osteogenesis imperfecta (OI) is a rare inherited disorder that causes bones to break easily. Individuals with osteogenesis imperfecta break bones often and may have other problems, including hearing loss and pain and difficulty getting around. People with moderate to severe OI may also be diagnosed with dentinogenesis imperfecta (DI). DI is characterized by grey or brown teeth that may chip and wear down and break easily. People with DI may also have skull and neck defects. These patients may have severe teeth misalignment resulting in clinically significant chewing problems. Teeth misalignment in OI is very hard to treat because of the quality and quantity of bone. The overall goal of this study is to improve dental health to improve the quality of life of people with OI.

Təsvir

Investigators will look at dental health in people with OI and will describe teeth misalignment and head and neck defects in individuals with moderate to severe Osteogenesis Imperfecta (OI).

Investigators will look at results from the Longitudinal study of OI to complete the study evaluations. Several x-rays will be performed for this study. Participants will have a 3D scan of the mouth and a Cone Beam CT scan of the jaw at a baseline visit and at 3 years after the baseline visit. These study visits can be at the same time as the Longitudinal Study of OI study visits.

Tarixlər

Son Doğrulandı:	03/31/2020
İlk təqdim:	10/11/2016
Təxmini qeydiyyat təqdim edildi:	10/12/2016
İlk Göndərmə:	10/16/2016
Son Yeniləmə Göndərildi:	04/06/2020
Son Yeniləmə Göndərildi:	04/07/2020
Həqiqi Təhsilin Başlama Tarixi:	07/31/2016
Təxmini İlkin Tamamlanma Tarixi:	12/31/2019
Təxmini İşin Tamamlanma Tarixi:	11/30/2020

Vəziyyət və ya xəstəlik

Osteogenesis Imperfecta

Faza

Uyğunluq Kriteriyaları

Təhsil üçün uyğun yaşlar	10 Years Üçün 10 Years
Təhsilə Uyğun Cinslər	All
Nümunə götürmə metodu	Probability Sample
Sağlam Könüllüləri qəbul edir	Bəli
Kriteriyalar	Inclusion Criteria: - Males and females with Clinical diagnosis of OI other than OI type I - Individuals 10 years or older - Participant of the Brittle Bone Disease (BBD) Longitudinal Study (7701) Exclusion Criteria: - Individuals who cannot be correctly positioned for valid radiographic analysis (e.g., due to severe scoliosis or short neck secondary to basilar invagination) - Women who are pregnant

Nəticə

İlkin nəticə tədbirləri

1. Measure teeth misalignment in individuals with moderate to severe OI using scans of the teeth. [5 years]

İkincili Nəticə Tədbirləri

1. Determine neck defects in individuals with moderate to severe OI using scans of the neck and jaw. [5 years]

Dental Malocclusion and Craniofacial Development in OI

Açar sözlər

büllur xəstəliyi

karlıq

dentinogenesis imperfecta

malocclusion