Dietary Phytosterols and Human Aortic Valve
Açar sözlər
Mücərrəd
Təsvir
High level of serum cholesterol is a risk factor for atherosclerotic complications, including atherosclerotic aortic valve disease. Over 50 years dietary plant sterols have been used to inhibit intestinal cholesterol absorption and to decrease its levels in serum. Daily human diet contains numerous different plant sterols, of which sitosterol and campesterol are the most abundant ones. Few epidemiologic studies suggest that sitosterol and campesterol may also be involved in formation of atherosclerotic changes in human arteries. The saturated forms of sitosterol and campesterol, i.e., the plant stanols (mainly sitostanol and campestanol) are beneficial with this respect. As part of daily diet, the plant stanols decrease absorption of both cholesterol and plant sterols, and thus, are putatively even more effective in prevention of atherosclerosis than the respective plant sterols.
Our double-blind controlled intervention study unravels influence of dietary plant sterols and stanols on the structure and the sterol composition of the human aortic valve.
50-60 patients, who will undergo aortic valve surgery, will be asked to volunteer our study. The patients will be randomized into three groups: (A) a group consuming margarine containing daily 2 grams plant stanols, (E) a group consuming margarine containing daily 2 grams of plant sterols, (C) a control group consuming margarine without any plant sterols or stanols. The dietary intervention will last for 4 to 8 weeks from the randomization to the operation.
Serum samples for analyses of serum lipids, lipoproteins and sterols will be collected at the randomization and at the operation. The atherosclerotic aortic valve will be examined with respect to its composition of cholesterol, other sterols and stanols.
The aim of our study is to elucidate the effects of dietary consumption of plant sterols and stanols on the sterol composition and structure of the atherosclerotic disease-affected aortic valve in human patients.
Tarixlər
| Son Doğrulandı: | 01/31/2011 |
| İlk təqdim: | 08/19/2008 |
| Təxmini qeydiyyat təqdim edildi: | 08/19/2008 |
| İlk Göndərmə: | 08/20/2008 |
| Son Yeniləmə Göndərildi: | 02/10/2011 |
| Son Yeniləmə Göndərildi: | 02/13/2011 |
| Həqiqi Təhsilin Başlama Tarixi: | 03/31/2008 |
| Təxmini İlkin Tamamlanma Tarixi: | 11/30/2011 |
| Təxmini İşin Tamamlanma Tarixi: | 11/30/2011 |
Vəziyyət və ya xəstəlik
Müdaxilə / müalicə
Dietary Supplement: A
Dietary Supplement: E
Dietary Supplement: C
Faza
Qol Qrupları
| Qol | Müdaxilə / müalicə |
|---|---|
| Active Comparator: A A group of patients consuming 2 grams plant stanols 4-8 weeks before the operation | Dietary Supplement: A Daily 2 grams of plant stanols in a margarine preparation for 4-8 weeks before the operation |
| Active Comparator: E A group of patients consuming daily 2 grams plant sterols 4-8 weeks before the operation. | Dietary Supplement: E Daily 2 grams of plant sterols in a margarine preparation for 4-8 weeks before the operation |
| Placebo Comparator: C | Dietary Supplement: C Margarine product without plant stanol or sterol esters |
Uyğunluq Kriteriyaları
| Təhsil üçün uyğun yaşlar | 40 Years Üçün 40 Years |
| Təhsilə Uyğun Cinslər | All |
| Sağlam Könüllüləri qəbul edir | Bəli |
| Kriteriyalar | Inclusion Criteria: - Atherosclerotic aortic valve disease needing an aortic valve replacement operation Exclusion Criteria: - None |
Nəticə
İlkin nəticə tədbirləri
1. Composition of serum and aortic valve sterols at the time of aortic valve operation [Up to 4 weeks]
