Endovascular Denervation in Patients With Peripheral Arterial Disease
Açar sözlər
Mücərrəd
Təsvir
Peripheral arterial disease(PAD) show insufficient blood supply of diseased limbs, which causes intermittent claudication of lower limbs, reduced skin temperature, pain, and chronic progressive disease that still produces ulcer or necrosis. Some clinical studies have shown Sympathetic overactivity in the lower arterial ischemic disease. The multi-electrode radiofrequency ablation system can significantly reduce the excitability of sympathetic nerve, restore the normal response of sympathetic nerve, relieve the pain and discomfort of patients, effectively improve the symptoms of lower limb ischemia, and improve the quality of life of patients.
Tarixlər
| Son Doğrulandı: | 07/31/2019 |
| İlk təqdim: | 08/15/2019 |
| Təxmini qeydiyyat təqdim edildi: | 08/15/2019 |
| İlk Göndərmə: | 08/18/2019 |
| Son Yeniləmə Göndərildi: | 08/15/2019 |
| Son Yeniləmə Göndərildi: | 08/18/2019 |
| Həqiqi Təhsilin Başlama Tarixi: | 08/12/2019 |
| Təxmini İlkin Tamamlanma Tarixi: | 08/31/2022 |
| Təxmini İşin Tamamlanma Tarixi: | 08/31/2023 |
Vəziyyət və ya xəstəlik
Müdaxilə / müalicə
Device: endovascular denervation
Faza
Qol Qrupları
| Qol | Müdaxilə / müalicə |
|---|---|
| Experimental: endovascular denervation endovascular denervation | Device: endovascular denervation multi-electrode catheter-based endovascular denervation |
Uyğunluq Kriteriyaları
| Təhsil üçün uyğun yaşlar | 18 Years Üçün 18 Years |
| Təhsilə Uyğun Cinslər | All |
| Sağlam Könüllüləri qəbul edir | Bəli |
| Kriteriyalar | Inclusion Criteria: - 18 to 75 years - Patients with established PAD with Rutherford Grade2-6 Exclusion Criteria: - pregnant or intent to become pregnant - Orthostatic hypotension - acute or severe systemic infection - uncorrected coagulation dysfunction - renal dysfunction - Patients that have allergy to contrast agent and nitinol - Myocardial infarction, unstable angina pectoris, coronary bypass or percutaneous angioplasty within 3 months before inclusion - Cerebrovascular accidents and alimentary tract hemorrhage within 3 months before inclusion - participants who are not suitable to be enrolled into the study assessed bythe researchers |
Nəticə
İlkin nəticə tədbirləri
1. Ischemia relief [from baseline to 1 months after procedure]
İkincili Nəticə Tədbirləri
1. Ischemia relief [from baseline to 3months after procedure]
2. pain relief [from baseline to 3 months after procedure]
