Microneedle and Trichloroaceticacid in Treatment of Melasma
Açar sözlər
Mücərrəd
Təsvir
As regards management, the therapeutic options range from photoprotection, topical hypopigmenting agents, chemical peels and lasers. There are variety of less-tried systemic agents like fish oil, green tea and . Although no single agent has proved to be effective for all patients, a combination of two or three agents is often tried to achieve optimum results.
Chemical peeling is the application of a chemical agent to the skin, which causes the controlled destruction of a part or of the entire epidermis, with or without the dermis, leading to exfoliation and removal of superficial lesions, followed by the regeneration of new epidermal and dermal tissues.
Chemical peels are a well-known modality of treatment for melasma. The basic mechanism of the action of chemical peels in melasma is the removal of unwanted melanin by causing a controlled chemical burn to the skin.
Trichlroacetic acid peeling has been the gold standard in chemical peeling for many decades.
For superficial peels Trichlroacetic acid 10% to 25% are used. some authors consider up to 35% Trichlroacetic acid as also a superficial.
Skin microneedling is a technique predominantly used to improve the appearance of cutaneous scarring and photo damage.
Fine needles puncture the skin, resulting in increased dermal elastin and collagen, collagen remodelling, and thickening of the epidermis and dermis. Additionally, skin needling creates small channels, which increase the absorption of topically applied preparations A property which has been used in various dermatological treatments.
Tarixlər
Son Doğrulandı: | 01/31/2018 |
İlk təqdim: | 02/06/2018 |
Təxmini qeydiyyat təqdim edildi: | 03/19/2018 |
İlk Göndərmə: | 03/20/2018 |
Son Yeniləmə Göndərildi: | 03/19/2018 |
Son Yeniləmə Göndərildi: | 03/20/2018 |
Həqiqi Təhsilin Başlama Tarixi: | 04/04/2018 |
Təxmini İlkin Tamamlanma Tarixi: | 04/04/2019 |
Təxmini İşin Tamamlanma Tarixi: | 04/04/2020 |
Vəziyyət və ya xəstəlik
Müdaxilə / müalicə
Device: Microneedle
Faza
Qol Qrupları
Qol | Müdaxilə / müalicə |
---|---|
Active Comparator: A include 20 patients will be treated with TCA25% +microneedle 8 sessions for TCA 25 peel and 4 sessions for microneedle (derma pen). | |
Active Comparator: B include 20 patient will be treated with TCA 25% only ( 8 sessions) |
Uyğunluq Kriteriyaları
Təhsil üçün uyğun yaşlar | 18 Years Üçün 18 Years |
Təhsilə Uyğun Cinslər | All |
Sağlam Könüllüləri qəbul edir | Bəli |
Kriteriyalar | Inclusion Criteria: - Both sex will be included Age range from 18- 50 yrs.' old Patients with realistic expectations. Exclusion Criteria: - patients taking oral contraceptive pills. patients with history of polycystic ovary. pregnant and lactating females. patients with active infection. patients on isotretinoin. patients with history of keloids,or hypertrophic scars. |
Nəticə
İlkin nəticə tədbirləri
1. Scoring of the patients according to modified melasma are abd severity index [mMASI] Scoring before and After last session will be done by 1 month [1 month after last session]
2. [mMASI] Scoring before and After last session will be done by 3 months [3 months after last session]