MRI to Assess Fibrosis in Eosinophilic Esophagitis Patients
Açar sözlər
Mücərrəd
Təsvir
MRI will be performed on a 1.5T magnet. Patients will be scanned in an oblique prone position similar to how esophageal distention is assessed at barium fluoroscopy. The following sequences and rationale will be used for the examination:
A sagittal 50mm thick multiphase FIESTA and multiphase SSFSE will be performed while the patient drinks water. The temporal resolution of the images will be approximately 1 image every 1.5-2 seconds. The images will be used to assess the lumen caliber and the wall thickness during maximal distension as pseudothickening can occur with decreased luminal distension.
Sagittal SSFSE with fat suppression, sagittal FRFSE T2-weighted images with fat suppression, axial DWI and sagittal DWI will be performed to asses for edema and inflammation within the esophageal wall.
axial FS SSFSE or FIESTA will be performed and targeted to the region of stricturing.
Dynamic sagittal imaging will be performed following IV contrast to assess for mural hyperenhancement which can be seen mural inflammation and delayed enhancement which can be seen in fibrosis. Sequential acquisitions will be performed beginning at 40 seconds following IV contrast injection. Delayed acquisitions will be performed at 5 min and 7 min. Patients will be asked to perform swallowing during the image acquisition to reduce the potential for pseudoenhancement secondary to under distension.
Tarixlər
| Son Doğrulandı: | 03/31/2020 |
| İlk təqdim: | 12/26/2017 |
| Təxmini qeydiyyat təqdim edildi: | 02/18/2018 |
| İlk Göndərmə: | 02/25/2018 |
| Son Yeniləmə Göndərildi: | 04/12/2020 |
| Son Yeniləmə Göndərildi: | 04/13/2020 |
| Həqiqi Təhsilin Başlama Tarixi: | 02/28/2017 |
| Təxmini İlkin Tamamlanma Tarixi: | 01/14/2021 |
| Təxmini İşin Tamamlanma Tarixi: | 07/14/2021 |
Vəziyyət və ya xəstəlik
Müdaxilə / müalicə
Device: MRI to detect inflammation and fibrosis in EoE patients
Faza
Qol Qrupları
| Qol | Müdaxilə / müalicə |
|---|---|
| Experimental: MRI to detect inflammation and fibrosis in EoE patients To assess through MRI the existence of an inflammatory and fibrotic component in strictures of eosinophilic esophagitis patients and to determine if this component is responsive to a therapeutic course of budesonide. | Device: MRI to detect inflammation and fibrosis in EoE patients MRI will be performed on a 1.5T magnet. Patients will be scanned in an oblique prone position similar to how esophageal distention is assessed at barium fluoroscopy |
Uyğunluq Kriteriyaları
| Təhsil üçün uyğun yaşlar | 18 Years Üçün 18 Years |
| Təhsilə Uyğun Cinslər | All |
| Sağlam Könüllüləri qəbul edir | Bəli |
| Kriteriyalar | Inclusion criteria: - Adults ages 18-70 years of age - Diagnosis of EoE, i.e. symptoms of esophageal dysfunction with histologic finding of 15 or more eosinophils per high power field on esophageal biopsy despite 8 weeks of high dose proton pump inhibitor therapy. - All Subjects diagnosed with Eosinophilic Esophagitis pre and pose therapy Exclusion criteria: - Clinical evidence of infectious process potentially contributing to dysphagia (e.g. candidiasis, CMV, herpes) - Other cause of dysphagia identified at endoscopy or esophagram (e.g. reflux esophagitis, stricture, web, ring, achalasia, esophageal neoplasm) - Esophageal minimal diameter < 13 mm on structured barium esophagram - Inability to read due to: Blindness, cognitive dysfunction, or English language illiteracy - Pregnant women - Presence of body metallic fragments or devices that prohibit use of MRI - History of renal disease - eGRF <30 |
Nəticə
İlkin nəticə tədbirləri
1. Measurement of distinct inflammatory and fibrotic components of the esophageal stricture in patients with eosinophilic esophagitis [1 day]
İkincili Nəticə Tədbirləri
1. Barium Esophagram [1 day]
2. Eosinophilic Esophagitis Activity Index (EEsAI) [1 day]
