Nabilone in Cannabis Users With PTSD
Açar sözlər
Mücərrəd
Təsvir
This study will compare the effects of smoked cannabis and nabilone on attentional bias toward trauma- related stimuli, subjective and emotional processing to a range of trauma-and non-trauma-related images and physiological reactivity to these stimuli in individuals with CUD and PTSD. Importantly, this study will also probe the abuse related potential of nabilone compared to smoked cannabis in this population, a critical aspect in determining the potential feasibility for its use clinically to treat CUD in PTSD populations. The effects of nabilone will be compared to propranolol as a positive control.
Tarixlər
Son Doğrulandı: | 10/31/2019 |
İlk təqdim: | 08/13/2017 |
Təxmini qeydiyyat təqdim edildi: | 08/13/2017 |
İlk Göndərmə: | 08/15/2017 |
Son Yeniləmə Göndərildi: | 11/05/2019 |
Son Yeniləmə Göndərildi: | 11/07/2019 |
Həqiqi Təhsilin Başlama Tarixi: | 09/30/2015 |
Təxmini İlkin Tamamlanma Tarixi: | 05/31/2019 |
Təxmini İşin Tamamlanma Tarixi: | 05/31/2019 |
Vəziyyət və ya xəstəlik
Müdaxilə / müalicə
Drug: Nabilone
Drug: Smoked cannabis
Drug: Propranolol
Drug: Placebo
Faza
Qol Qrupları
Qol | Müdaxilə / müalicə |
---|---|
Experimental: Nabilone Nabilone capsules (4 mg) | Drug: Nabilone Nabilone capsules (4 mg) |
Active Comparator: Propranolol Propranolol capsules (40mg) | Drug: Propranolol Propranolol capsules (40mg) |
Experimental: Smoked cannabis (0.0 and 5.6% THC) | Drug: Smoked cannabis Cigarettes (0.0 and 5.6% THC) |
Placebo Comparator: Placebo Placebo capsules | Drug: Placebo Placebo capsules |
Uyğunluq Kriteriyaları
Təhsil üçün uyğun yaşlar | 21 Years Üçün 21 Years |
Təhsilə Uyğun Cinslər | All |
Sağlam Könüllüləri qəbul edir | Bəli |
Kriteriyalar | Inclusion Criteria: - Current cannabis use - PTSD symptoms - Able to give informed consent and comply with study procedures - Women who are normally cycling and practicing an effective form of birth control other than hormonal contraceptives Exclusion Criteria: - Meeting criteria for certain current psychiatric disorders - Clinical laboratory tests outside of normal limits - History of clinically significant cardiac or respiratory diagnoses - Current parole or probation - Women who are currently pregnant or breastfeeding |
Nəticə
İlkin nəticə tədbirləri
1. Cue Reactivity [1 month]