Nabilone in Cannabis Users With PTSD

Yalnız qeydiyyatdan keçmiş istifadəçilər məqalələri tərcümə edə bilərlər

Giriş / Qeydiyyatdan keçin

Bağlantı panoya saxlanılır

StatusXitam verilib

Sponsorlar

New York State Psychiatric Institute

Əməkdaşlar

National Institute on Drug Abuse (NIDA)

KLINIK SINAQ: NCT03251326

BioSeek: nct03251326

Açar sözlər

Mücərrəd

Despite the prevalence of cannabis use among the PTSD population and self-reports that it is used to help cope with PTSD symptoms, the direct effects of cannabis on PTSD symptomology are unknown. The purpose of this placebo-controlled, within-subject study is to assess the effects of smoked cannabis and orally administered nabilone, a synthetic analog of THC, the primary psychoactive component of cannabis on multiple dimensions of PTSD symptomatology in cannabis smokers with PTSD.

Təsvir

This study will compare the effects of smoked cannabis and nabilone on attentional bias toward trauma- related stimuli, subjective and emotional processing to a range of trauma-and non-trauma-related images and physiological reactivity to these stimuli in individuals with CUD and PTSD. Importantly, this study will also probe the abuse related potential of nabilone compared to smoked cannabis in this population, a critical aspect in determining the potential feasibility for its use clinically to treat CUD in PTSD populations. The effects of nabilone will be compared to propranolol as a positive control.

Tarixlər

Son Doğrulandı:	10/31/2019
İlk təqdim:	08/13/2017
Təxmini qeydiyyat təqdim edildi:	08/13/2017
İlk Göndərmə:	08/15/2017
Son Yeniləmə Göndərildi:	11/05/2019
Son Yeniləmə Göndərildi:	11/07/2019
Həqiqi Təhsilin Başlama Tarixi:	09/30/2015
Təxmini İlkin Tamamlanma Tarixi:	05/31/2019
Təxmini İşin Tamamlanma Tarixi:	05/31/2019

Vəziyyət və ya xəstəlik

Cannabis

Post Traumatic Stress Disorder

Müdaxilə / müalicə

Drug: Nabilone

Drug: Smoked cannabis

Drug: Propranolol

Drug: Placebo

Faza

Faza 1/Faza 2

Qol Qrupları

Qol	Müdaxilə / müalicə
Experimental: Nabilone Nabilone capsules (4 mg)	Drug: Nabilone Nabilone capsules (4 mg)
Active Comparator: Propranolol Propranolol capsules (40mg)	Drug: Propranolol Propranolol capsules (40mg)
Experimental: Smoked cannabis (0.0 and 5.6% THC)	Drug: Smoked cannabis Cigarettes (0.0 and 5.6% THC)
Placebo Comparator: Placebo Placebo capsules	Drug: Placebo Placebo capsules

Uyğunluq Kriteriyaları

Təhsil üçün uyğun yaşlar	21 Years Üçün 21 Years
Təhsilə Uyğun Cinslər	All
Sağlam Könüllüləri qəbul edir	Bəli
Kriteriyalar	Inclusion Criteria: - Current cannabis use - PTSD symptoms - Able to give informed consent and comply with study procedures - Women who are normally cycling and practicing an effective form of birth control other than hormonal contraceptives Exclusion Criteria: - Meeting criteria for certain current psychiatric disorders - Clinical laboratory tests outside of normal limits - History of clinically significant cardiac or respiratory diagnoses - Current parole or probation - Women who are currently pregnant or breastfeeding

Nəticə

İlkin nəticə tədbirləri

1. Cue Reactivity [1 month]

Emotional Stroop Task