Neurotransmitter Measurements Using (WINCS) During Deep Brain Stimulation Neurosurgery
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Mücərrəd
Təsvir
In this study, the investigators will monitor extracellular neurotransmitter levels using a probe that is able to perform realtime electrochemical detection during DBS neurosurgery. The overall question this study is designed to answer is: Are there neurotransmitters released during deep brain stimulation? We propose to enroll 45 patients (15 patients each at the three targets for DBS) with Essential Tremor, Parkinson's Disease, and Dystonia who are undergoing DBS neurosurgery. This will be an acute study. Patients with medically identifiable symptoms of the above diseases who have been approved by Mayo DBS committee for implantation of DBS will be selected for this study. These patients will then be consented preoperatively to undergo extracellular electrophysiology which is typical in these cases to determine the target site for implantation of the DBS electrodes. Following this electrophysiologic procedure, the patient will have electrochemical electrode implanted to (1) determine whether there is adenosine release at the site of stimulation during ventral intermediate nucleus (VIM) thalamic DBS, (2) determine whether there is dopamine and adenosine release within the caudate nucleus or putamen during subthalamic nucleus DBS, and (3) determine whether there is dopamine and adenosine release at the site of stimulation during Globus Pallidus DBS.
Tarixlər
Son Doğrulandı: | 07/31/2017 |
İlk təqdim: | 10/08/2012 |
Təxmini qeydiyyat təqdim edildi: | 10/10/2012 |
İlk Göndərmə: | 10/11/2012 |
Son Yeniləmə Göndərildi: | 07/31/2017 |
Son Yeniləmə Göndərildi: | 08/02/2017 |
Həqiqi Təhsilin Başlama Tarixi: | 12/31/2009 |
Təxmini İlkin Tamamlanma Tarixi: | 07/26/2017 |
Təxmini İşin Tamamlanma Tarixi: | 07/26/2017 |
Vəziyyət və ya xəstəlik
Müdaxilə / müalicə
Device: Deep Brain Stimulation
Faza
Qol Qrupları
Qol | Müdaxilə / müalicə |
---|---|
Deep Brain Stimulation Patient's undergoing the clinical procedure of Deep Brain Stimulation will have the experimental protocol that involves, after implantation of the DBS electrodes, a single electrochemical recording electrode, from the WINCS system, implanted along the same trajectory path as the electrophysiology and the DBS electrode | Device: Deep Brain Stimulation The experimental protocol will involve, after implantation of the DBS electrodes, the patient will have a single electrochemical recording electrode will be implanted along the same trajectory path as the electrophysiology and the DBS electrode |
Uyğunluq Kriteriyaları
Təhsil üçün uyğun yaşlar | 18 Years Üçün 18 Years |
Təhsilə Uyğun Cinslər | All |
Nümunə götürmə metodu | Probability Sample |
Sağlam Könüllüləri qəbul edir | Bəli |
Kriteriyalar | Inclusion Criteria: - adult Patients with medically intractable Essential Tremor, Parkinson's Disease, and Dystonia who have been approved for DBS surgery by the interdisciplinary Mayo DBS committee. Exclusion Criteria: - pregnant patients, - prisoners, - children (age less than 18), and - any patients identified as unsuitable for these protocol by the Mayo DBS committee. |
Nəticə
İlkin nəticə tədbirləri
1. adenosine release in brain as measured by WINCS (Wireless Instantaneous Neurochemical Concentration Sensing System)recording device [30 minutes]
İkincili Nəticə Tədbirləri
1. dopamine release in brain as measured by WINCS (Wireless Instantaneous Neurochemical Concentration Sensing System)recording device [30 minutes]