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Obesity and Antibiotic Tissue Concentration

Yalnız qeydiyyatdan keçmiş istifadəçilər məqalələri tərcümə edə bilərlər
Giriş / Qeydiyyatdan keçin
Bağlantı panoya saxlanılır
StatusTamamlandı
Sponsorlar
MemorialCare
Əməkdaşlar
University of California, Irvine

Açar sözlər

Mücərrəd

The purpose of this study is to determine whether the dose of prophylactic antibiotics at the time of cesarean delivery requires adjustment in obese and overweight patients in order to achieve optimal antimicrobial activity.

Təsvir

The majority of information regarding pharmacokinetics and pharmacodynamics (the action, properties and elimination of a drug in the body) of antibiotics is based on measurements of the serum and plasma concentrations. Current guidelines for surgical antibiotic prophylaxis have clearly demonstrated appropriate therapeutic levels within blood and serum levels, resulting in low incidence of postoperative bacteremia (bacteria in the blood) and sepsis (infection). Despite this, surgical site infections (SSI) remain the most common postoperative complication, affecting up to 20% of patients undergoing intra-abdominal surgery. Inadequate antibiotic penetration into the tissues of the surgical site, in spite of therapeutic serum levels, results in an environment that is susceptible to pathogens and subsequent infections. Antimicrobial tissue levels are influenced by volume of distribution, regional blood flow and biological properties of tissue. The ability of any drug to reach the tissue of interest is dictated by the relative amount of blood flow to that organ. While lungs and kidneys enjoy a robust blood supply, subcutaneous adipose tissue (fat) (the most frequent site of surgical site infections) receives a small fraction of the cardiac output. Obesity creates an increased volume of distribution, thereby resulting in a greater dilution of antibiotics when compared to non-obese subjects. Moreover, this change in volume of distribution is achieved primarily by increasing the relative amount of poorly perfused adipose tissue. Therefore, it should come as no surprise that obesity is a significant risk factor for surgical site infections.

The rate of obesity in the United States has shown a steady increase and more than doubled in the last twenty-five years from 15% in 1980 to 32.9% in 2004. Moreover, nearly one third of women of reproductive age are obese and approximately 6% are extremely obese. In addition to the usual health related concerns, obesity significantly increases the rate of complications associated with pregnancy. In particular, several studies have demonstrated an increased incidence of cesarean delivery associated to maternal obesity. Cesarean delivery rates, much like obesity rates, have witnessed a tremendous surge in the last few decades and now account for approximately 30% of all deliveries or nearly 1.2 million procedures. Surgical site infections associated with cesarean delivery include wound infections and endomyometritis (infection in the uterus), with rates ranging from 7% to 20% depending on the demographic and obstetric variables. Despite these alarming trends there is a paucity of data regarding antimicrobial activity of prophylactic antibiotics in tissues and the effects of maternal obesity on these concentrations at the time of cesarean delivery.

While the rates of cesarean deliveries have reached a plateau at around 30% in recent years, the rates of obesity continue to climb unabated. As the attributes of the population evolve over the course of time so must the guidelines and management adapt to the individuals in our care.

Tarixlər

Son Doğrulandı: 08/31/2010
İlk təqdim: 09/17/2009
Təxmini qeydiyyat təqdim edildi: 09/17/2009
İlk Göndərmə: 09/20/2009
Son Yeniləmə Göndərildi: 10/06/2010
Son Yeniləmə Göndərildi: 10/07/2010
Həqiqi Təhsilin Başlama Tarixi: 05/31/2009
Təxmini İlkin Tamamlanma Tarixi: 05/31/2010
Təxmini İşin Tamamlanma Tarixi: 05/31/2010

Vəziyyət və ya xəstəlik

Obesity

Faza

-

Qol Qrupları

QolMüdaxilə / müalicə
BMI <30
BMI <30
BMI 30-39
BMI 30-39
BMI >40
BMI >40

Uyğunluq Kriteriyaları

Təhsil üçün uyğun yaşlar 18 Years Üçün 18 Years
Təhsilə Uyğun CinslərFemale
Nümunə götürmə metoduNon-Probability Sample
Sağlam Könüllüləri qəbul edirBəli
Kriteriyalar

Inclusion Criteria:

- Patients at term (> 37 weeks) undergoing a cesarean delivery.

Exclusion Criteria:

- Women younger than 18 years,

- Pre-gestational diabetes,

- Chronic hypertension,

- Collagen vascular disease,

- Multiple gestation,

- Contraindications to cefazolin administration (known anaphylactic reaction to penicillins or known cephalosporin allergy),

- Any exposure to cephalosporins in one week prior to cesarean section, OR

- Need for emergent cesarean delivery or diagnosis of chorioamnionitis.

Nəticə

İlkin nəticə tədbirləri

1. To assess the effects of maternal obesity on the concentrations and adequacy of antimicrobial activity of prophylactically administered antibiotics within tissues (subcutaneous adipose and myometrial) at the time of cesarean delivery. [6 weeks]

İkincili Nəticə Tədbirləri

1. To assess the concentrations and adequacy of antimicrobial activity of prophylactically administered antibiotics within tissues (subcutaneous adipose and myometrial) at the time of cesarean delivery. [6 weeks]

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