Risperidone-Induced Hyperprolactinemia Treated With Bromocriptine
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Mücərrəd
Təsvir
Antipsychotic drugs can cause a clinically relevant hyperprolactinemia due to blocking the dopamine receptors in the pituitary.Depending on its concentration hyperprolactinemia causes a median hypogonadism with estrogen insufficiency in women and testosterone insufficiency in men by inhibiting the pulsatile GnRH-secretion.The hyperprolactinemia-induced symptoms have been successfully medicated for years with dopamine agonists like bromocriptine.
In patients with psychiatric diseases hyperprolactinemia is usually not treated with dopamine agonist fearing a reexacerbation of the underline psychiatric disease. In a few studies and casuistically the treatment of neuroleptic-induced hyperprolactinemia with bromocriptine has been shown to be effective without causing reexacerbation of psychotic symptoms.
Schizophrenic patients suffering from a neuroleptic-induced hyperprolactinemia (in extremis galactorrhoea and amenorrhoea. in women, loss of libido and erectile dysfunction in men) will be examined endocrinologically. Adverse drug effects and diagnoses will be confirmed by measuring hormones (prolactin, LH, FSH, testosterone, estradiol). In case of a clear symptomatic, neuroleptic-induced hyperprolactinemia patients will be medicated with bromocriptin. Therapeutical success will be determined endocrinologically in week 0, 1, 2, 3, 4, 8, 12, 16, 20 and 24 together with a psychiatric examination (PANSS, HAM-D, Simpson-Angus Scale (SAS)). Safety of therapy will be ensured by the close meshed psychiatric examinations.
Tarixlər
| Son Doğrulandı: | 10/31/2005 |
| İlk təqdim: | 04/12/2006 |
| Təxmini qeydiyyat təqdim edildi: | 04/12/2006 |
| İlk Göndərmə: | 04/16/2006 |
| Son Yeniləmə Göndərildi: | 04/12/2006 |
| Son Yeniləmə Göndərildi: | 04/16/2006 |
| Həqiqi Təhsilin Başlama Tarixi: | 04/30/2006 |
| Təxmini İşin Tamamlanma Tarixi: | 04/30/2008 |
Vəziyyət və ya xəstəlik
Müdaxilə / müalicə
Drug: Bromocriptin
Faza
Uyğunluq Kriteriyaları
| Təhsil üçün uyğun yaşlar | 18 Years Üçün 18 Years |
| Təhsilə Uyğun Cinslər | Male |
| Sağlam Könüllüləri qəbul edir | Bəli |
| Kriteriyalar | Inclusion Criteria: - Female and male schizophrenic patients. - Antipsychotic treatment with risperidone. - Diagnosis of a clinically relevant hyperprolactinemia. - No indication of disturbance of the somato-, cortico or thyreotropic hypophysis-axis (IGF-1, cortisol, ACTH, TSH, FT3, FT4) Exclusion Criteria: - Severe somatic disease, especially coronary disease. - Acute psychotic exacerbation. - Pregnancy |
Nəticə
İlkin nəticə tədbirləri
1. Prolactin [undefined]
2. LH [undefined]
3. FSH [undefined]
4. Testosterone [undefined]
5. Estradiol [undefined]
İkincili Nəticə Tədbirləri
1. PANSS [undefined]
2. HAM-D [undefined]
3. Simpson Angus Scale (SAS) [undefined]
