Treatment of Orthostatic Hypotension

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Giriş / Qeydiyyatdan keçin

Bağlantı panoya saxlanılır

Status

Sponsorlar

Vanderbilt University

KLINIK SINAQ: NCT00581477

BioSeek: nct00581477

Açar sözlər

Mücərrəd

The purpose of this study is to try different medications in patients with low blood pressure and other problems with their involuntary (autonomic) nervous system. The pharmacological trials in this study will perhaps lead to more effective treatment. This study consists of single dose trials, dose selection trials, 5-day trials and chronic (approximately 2 months) trials.

Təsvir

We see many patients at the Autonomic Dysfunction Center who can be given a fairly definitive diagnosis, e.g., Orthostatic Intolerance, Pure Autonomic Failure, Multiple System Atrophy, and Baroreflex Failure. However, some patients present with a unique constellation of symptoms of autonomic dysfunction so that they do not fit into a diagnostic category. We hypothesize that a genetic cause exists in some of these patients. We further propose that our comprehensive evaluation of these patients will provide us with information on the pathophysiology of their condition and assist us in optimizing their treatment.

Tarixlər

Son Doğrulandı:	01/31/2020
İlk təqdim:	12/21/2007
Təxmini qeydiyyat təqdim edildi:	12/21/2007
İlk Göndərmə:	12/26/2007
Son Yeniləmə Göndərildi:	02/05/2020
Son Yeniləmə Göndərildi:	02/06/2020
Həqiqi Təhsilin Başlama Tarixi:	12/31/2003
Təxmini İlkin Tamamlanma Tarixi:	11/30/2020
Təxmini İşin Tamamlanma Tarixi:	11/30/2020

Vəziyyət və ya xəstəlik

Autonomic Nervous System Diseases

Orthostatic Hypotension

Dopamine Beta-Hydroxylase Deficiency

Orthostatic Intolerance

Müdaxilə / müalicə

Drug: 1

Drug: 2

Drug: 1

Faza

Faza 3

Qol Qrupları

Qol	Müdaxilə / müalicə
Placebo Comparator: 2	Drug: 2 same frequency as experimental medication
Experimental: 1	Drug: 1 up to 300mg four times daily

Uyğunluq Kriteriyaları

Təhsil üçün uyğun yaşlar	18 Years Üçün 18 Years
Təhsilə Uyğun Cinslər	All
Sağlam Könüllüləri qəbul edir	Bəli
Kriteriyalar	Inclusion Criteria: - patients with severe orthostatic hypotension and other autonomic symptoms who do not meet criteria for one of our standard diagnoses - non-smokers - drug-free - able to give informed consent - free of pulmonary, renal, hematopoietic, hepatic and cardiac disease Exclusion Criteria: - medications affecting the autonomic nervous system - any chronic illness (cardiac, pulmonary, endocrine, gastrointestinal, rheumatologic) - anemia (Hct < 30) - women of childbearing age who are pregnant or nursing - smokers

Nəticə

İlkin nəticə tədbirləri

1. Change in blood pressure with standing [following 5 days of medication]

İkincili Nəticə Tədbirləri

1. length of time subject is able to stand [following 5 days of medication]