[A case report of exercise-induced anaphylaxis].

We report a case of 44-year-old Japanese man who presented with exercise-induced anaphylaxis. He was admitted to our hospital with chief complaints of repeated episodes of urticaria and nausea induced by exercise. He had allergy to the radiologic contrast iodine material, but no history of atopic dermatitis. Physical and neurological examinations were unremarkable. Treadmill test induced urticaria and nausea in 10 minutes after starting the exercise and the test was discontinued. The systolic blood pressure finally fell down to 51mmHg about 17 minutes after ceasing the exercise, and it returned to normal value with hydrocortisone and noradrenalin injection. Treadmill test increased the serum histamine level, but did not increase serotonin nor IgE levels. Administration of antihistamines and avoidance of hard exercise has protected him from a new attack. We have to pay attention to exercise-induced anaphylaxis as one of the important causes of syncope.