Yao xue xue bao = Acta pharmaceutica Sinica 2005-Oct
[Alkaloids from the root of Lindera angustifolia].
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OBJECTIVE
To study the alkaloid constituents of the root of Lindera angustifolia Cheng.
METHODS
The constituents were isolated and purified by column chromatography and the structures were characterized by spectral analysis.
RESULTS
Seven aporphine alkaloids, laurotetanine (I), N-methyllaurotetanine (II), boldine (III), isoboldine (IV), norboldine (V), N-ethoxycarbonyllaurotetanine (VII) and a quaternary isoquinoline alkaloid, magnocurarine (VI), were isolated and identified. The structure of VII was further identified by semi-synthesis with I as starting material.
CONCLUSIONS
All compounds were obtained from this plant for the first time and compound VII was found as a naturally occurring compound for the first time.
