Journal of Natural Products 2008-Jun
Alpha-glucosidase inhibitor from Kothala-himbutu (Salacia reticulata WIGHT).
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A polyhydroxylated cyclic 13-membered sulfoxide (1) was isolated from an aqueous extract of Kothala-himbutu ( Salacia reticulata WIGHT). The structure of compound 1 was elucidated by 1D and 2D NMR and APCI-MS methods. The alpha-glucosidase inhibitory activity of compound 1 (IC 50: maltase, 0.227 microM; sucrase, 0.186 microM; isomaltase, 0.099 microM) was much greater than the inhibitory activity of salacinol and kotalanol, which were previously isolated from Kothala-himbutu.
