Presse Medicale 2008-Jun
[Bilateral papillary necrosis during indinavir treatment].
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BACKGROUND
Papillary necrosis results from ischemia of the renal medulla and papillae, induced by a variety of mechanisms. Papillary necrosis is a rare adverse effect of continuous protease-inhibitor therapy with indinavir.
METHODS
We describe the case of a patient who developed bilateral papillary necrosis. It was reversible after treatment interruption and increased hydration.
CONCLUSIONS
This case shows the need to monitor kidney markers in patients under continuous treatment with indinavir.