Evaluation of anti-inflammatory and analgesic properties of L-glutamine.

It was established that L-glutamine, an aminoacid, has marked anti-inflammatory activity and moderate analgesic activity. The drug was effective orally in suppressing various experimentally induced inflammatory reactions and did not show any gastric irritation in anti-inflammatory doses. It is observed that the anti-inflammatory effect of L-glutamine is not due to counter irritant action. It is suggested that it may partially mediate its anti-inflammatory activity by interfering with the action and/or synthesis of prostaglandins. Its anti-inflammatory activity is comparable to that of phenylbutazone and merits further study.