Carotid Artery Injuries

Performing an OCT-angiography and SD-OCT examination

OCT-angiography and SD-OCT

CHU Henri-Mondor

Imagery of Retinal and Choroidal Variations Observed After a Revascularization Procedure on the Internal Carotid Artery

Multimodal Imaging Analysis, OCT-angiography (Optical Coherence Tomography) and SD-OCT (Spectral Domain Optical Coherence Tomography), of Retinal and Choroidal Variations Observed After a Revascularization Procedure on the Internal Carotid Artery

Finely describe the homolateral retinal and choroidal vascular density changes in the macula in OCT-angiography at 1 month after revascularization on the internal carotid artery

Describe the variations of vascular density in OCT-A on the controlateral eye after revascularization

Describe the variations of subfoveal choroidal thickness in OCT-EDI (Enhanced depth imaging optical coherence tomography) after revascularization

Describe the variations in homolateral optical fiber thickness in RNFL ( Retinal Nerve Fiber Layer)OCT after revascularization

Compare the retinal and choroidal variations according to the proposed procedure: conventional surgery or angioplasty and stenting

Compare changes in intraocular pressure before and after revascularization procedure

Compare changes in retinal and choroidal vascular density according to the type of carotid stenosis: symptomatic stenosis, asymptomatic stenosis

Centre Hospitalier Intercommunal Creteil

All high risk surgical patients undergoing transcarotid revascularization with a carotid stent during carotid artery flow reversal in hospitals that participate in the Carotid Artery Stent Registry of the Society for Vascular Surgery Patient Safety Organization

All patients undergoing carotid endarterectomy in hospitals that participate in the Carotid Endarterectomy Registry of the Society for Vascular Surgery Patient Safety Organization

Carotid Artery Disease

Direct implantation of a stent into the carotid artery via a surgical incision in the neck combined with blood flow reversal in the carotid artery during stent placement

Transcarotid artery revascularization

Removal of carotid atherosclerotic plaque (endarterectomy) via a surgical incision in the neck

Carotid endarterectomy

Society for Vascular Surgery Patient Safety Organization

SVS VQI TransCarotid Revascularization Surveillance Project

TransCarotid Revascularization Surveillance Project of the Society for Vascular Surgery Vascular Quality Initiative

Any death or stroke in the territory of the treated carotid artery within one year of the carotid artery treatment

Any stroke or death within 30 days of the carotid artery treatment

Any stroke, death or myocardial infarction within 30 days of the carotid artery treatment

in phosphate buffered saline (PBS), 1% sucrose, 4% mannitol

Carotid Stenosis

Atherosclerosis

Stroke

Transient-ischaemic Attack

Amaurosis Fugax

Revacept

Placebo

Site 01: Department of Neurology, TU Munich

Site 08: Universitätsklinikum Essen, Klinik für Neurologie

Site 11: Universitätsklinikum Hamburg Eppendorf

Site 07: Medizinische Hochschule Hannover, Klinik für Neurologie

Site 12: Universitätsklinikum Leipzig AöR

Site 09: Universitätsmedizin Mainz, Klinik und Poliklinik für Neurologie

Site 04: Universitätsklinikum Tübingen, Klinik für Allgemeine Neurologie

Site 06: Universitätsklinikum Ulm, Abteilung für Neurologie

Site 23 - University Hospital Coventry NHS Trust

Site 26 - University College London Hospital

Site 28 - King's College London Hospital

Site 20: St George's NHS Trust

Revacept in Symptomatic Carotid Stenosis (Revacept/CS/02)

Revacept, an Inhibitor of Platelet Adhesion in Symptomatic Carotid Stenosis: A Phase II, Multicentre; Randomised, Dose-finding, Double-blind and Placebo Controlled Superiority Study With Parallel Groups

In patients with symptomatic carotid artery stenosis who have been treated with Revacept plus antiplatelet monotherapy versus antiplatelet monotherapy alone (placebo). MES will be assessed by transcranial Doppler (TCD) examination.

myocardial infarction and re-intervention

including wound healing complications, laboratory abnormalities and use of concomitant medication

laboratory parameters indicating thrombocytopenia and bleeding according to the RE-LY study group criteria, in vitro platelet function, in vitro bleeding time by PFA-100 / PFA-200

amaurosis fugax/insult

Imagery of Retinal and Choroidal Variations Observed After a Revascularization Procedure on the Internal Carotid Artery

SVS VQI TransCarotid Revascularization Surveillance Project

Revacept in Symptomatic Carotid Stenosis (Revacept/CS/02)

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