Participants will take part in 12 one-hour rehabilitation sessions over 12 weeks in the clinic at Holland Bloorview Kids Rehabilitation Hospital and Institut de réadaptation en déficience physique de Québec, during which they will play games developed for the Novint Falcon.

Cerebral Palsy

The Falcon contains a selection of 25+ games that require wrist extension and challenges children to grasp the controller with their affected hand. As children progress, they may advance to more difficult games that challenge the child to work against a resistance and/or apply greater grip forces. Therapists will be trained on the system, games, and given a guide summarizing the available games and the motor function areas targeted in the game. Using this guide, therapists can choose the games that are most suited to the child's abilities and goals. As multiple games will target many of the same motor function areas, children will have the option of choosing the games they like best to maximize motivational value. While this introduces some variability in the intervention, this flexibility is required to ensure that the therapy is targeting the specific interests, needs and goals of each individual child and is reflective of how ICP is used in a clinic setting.

Falcon

Holland Bloorview Kids Rehabilitation Hospital

Centre interdisciplinaire de recherche en réadaptation et en intégration sociale

Project Falcon: Exploring a Virtual Reality-based Video Game for Young People With Cerebral Palsy

Project Falcon: Exploring a Virtual Reality-based Video Game With Haptic Feedback for Sensory-motor Rehabilitation of Young People With Cerebral Palsy

The Canadian Occupational Performance Measure evaluates changes in perceived function and satisfaction of performance in self-identified goal areas. The child and parent work together with the therapist to identify 1-3 goals of interest. For each goal area, the child/parent ranks its importance, performance and satisfaction on a scale of 1-10. A higher rating indicates a more positive outcome.

A sphygmomanometer is used to measure grip strength of the hand by determining the amount of pressure (mmHg) that the hand can apply.

A goniometer is used to measure degrees of active/passive range of motion of the wrist.

Children's Hand-use Experience Questionnaire (CHEQ) is a 29 item child- or parent- completed questionnaire that examines how the weaker/affected limb is used in everyday activities. It presents a list of common daily activities that typically require use of two hands.The minimum score value is 0 and the maximum score value is 100. A higher score means a better outcome.

Consists of 10 pairs of statements scored on a 5-point Likert scale that probe factors in enjoyment of physical activity. The minimum score value is 1 and the maximum score value is 5. A higher score means a better outcome.

Custom feedback questionnaires will be used to evaluate the perceived quality of feedback, motivation, and difficulty of tasks during ICP therapies. It is based on validated questionnaires for measuring usability (SUS) and enjoyment (Flow short) and a custom questionnaire used in a previous study investigating ICP therapy games with this population. The custom feedback questionnaire consists of open-ended questions.
Open-ended questions include: What did you like about the games? What didn't you like about the games? What would make the games more fun?

16 patients with intractable abnormal movement disorders (Parkinson's disease, Essential tremors and Dystonia)

Parkinson Disease, Essential Tremors and Dystonia

stimulation of different basal ganglionic nuclei by a inserting a device

Deep Brain Stimulation

DBS in the Treatment of Intractable Movement Disorders

Deep Brain Stimulation in the Treatment of Intractable Movement Disorders ( Parkinson's Disease, Essential Tremors and Dystonia)

The Unified Parkinson's Disease Rating Scale (UPDRS) is a commonly used survey tool used to assess symptom severity of patients with Parkinson's disease (PD). It covers several different domains including 1) thought, behavior and mood 2) activities of daily living 3) motor activity 4) complications of therapy and others.
Part I: evaluation of mentation, behavior, and mood Part II: self-evaluation of the activities of daily life (ADLs) including speech, swallowing, handwriting, dressing, hygiene, falling, salivating, turning in bed, walking, and cutting food Part III: clinician-scored monitored motor evaluation Part IV: complications of therapy Part V: Hoehn and Yahr staging of severity of Parkinson's disease Part VI: Schwab and England ADL scale

the percent in reduction of antiparkinsonian medications used after DBS

Ahmed Radwan Nouby

Assistant Lecturer in the Department of Neurosurgery

Assiut University

Mct8 (Slc16A2)-Specific Thyroid Hormone Cell Transporter Deficiency

MCT8 mutation carrier mother with previously affected MCT8 deficient male will be screened for male fetal DNA as soon as she aware she is pregnant (week 4-7).

Diiodothyropropionic acid

University of Miami, Miller School of Medicine

Rescue of Infants With MCT8 Deficiency

Rescue of Infants With MCT8 Deficiency Under Emergency Use Single Patient Expanded Access Treatment

Roy E. Weiss, M.D.

Principal Investigator

Constraint induced movement therapy(prolonged restraint)consists of a combination of prolonged restraint of the unaffected upper limb and massed practice of the affected upper limb over a forty-two day period.

Constraint induced movement therapy(manual restraint)consists of a combination of manual restraint of the unaffected upper limb and massed practice of the affected upper limb over a forty-two day period.

A combination of prolonged restraint of the unaffected upper limb and massed practice of the affected upper limb.

Constraint Induced Movement Therapy

A Trial Comparing Two Methods of CIMT in the Hemiplegic Child

Randomised Controlled Trial to Compare Two Methods of Constraint Induced Movement Therapy to Improve Functional Ability in the Affected Upper Limb in Pre-school Children With Hemiplegic Cerebral Palsy

The Assisting Hand Assessment (AHA) (Krumlinde-Sundholm et al 2007) measures and describes the effectiveness with which a child with unilateral disability makes use of their affected hand in bimanual activity.It is a well evaluated measure appropriate for hand function in hemiplegia.

athetosis/asthenia

Project Falcon: Exploring a Virtual Reality-based Video Game for Young People With Cerebral Palsy

DBS in the Treatment of Intractable Movement Disorders

Rescue of Infants With MCT8 Deficiency

A Trial Comparing Two Methods of CIMT in the Hemiplegic Child

Elm tərəfindən dəstəklənən ən tam dərman bitkiləri bazası