Patients receive oral Boswellia serrata extract 4 times a day and oral cyanocobalamin (vitamin B 12) once a day for 6 months in the absence of unacceptable toxicity.

Patients in the control arm receive oral cyanocobalamin (vitamin B 12) once a day for 6 months.

Patients receive oral Boswellia serrata extract 4 times a day and oral cyanocobalamin (vitamin B 12) once a day for 6 months in the absence of unacceptable toxicity.
cyanocobalamin : 50 ug/day given orally
Boswellia serrata extract : 4x (3-12.5) ml/day given orally, that is 720-3000mg of total Boswellic acids (three isomers)/day

Arm I (Intervention)

Patients in the control arm receive oral cyanocobalamin (vitamin B 12) once a day for 6 months.
cyanocobalamin : 50 ug/daygiven orally

Arm II (Control)

Total

Age, Customized

Sex: Female, Male

Ethnicity (NIH/OMB)

Race (NIH/OMB)

Region of Enrollment

Baseline measure was acquired for 11 patients. Six on Arm I and five on Arm II.

Baseline edema measure

The relative change from baseline will be assessed longitudinally, however, the main comparison of interest is the relative change at the 4-month evaluation. For each patient change = edema at follow up - baseline edema

Change From Pooled Baseline in Peritumoral Brain Edema

The relative change from baseline will be assessed longitudinally, however, the main comparison of interest is the relative change at the 4-month evaluation.For each patient change = edema at follow up - baseline edema.

Change From Baseline in Peritumoral Brain Edema

The relative change from baseline will be assessed longitudinally, however, the main comparison of interest is the relative change at the 4-month evaluation. For each patient change = edema at follow up - baseline edema.

Quality of life as assessed by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 Items (EORTC QLQ-C30)

Quality of Life at 6 Months

Percentage of participants with tumor progression (>25% increase in tumor volume compared to time 0) will be measured from enrollment to documented progression or death whichever comes first. The method used to calculate the time to tumor progression was Kaplan Meier test method to define the 95% confidence levels.

Time-to-tumor-progression: Percentage of Patients With Tumor Progression at 6 Months

Time-to-tumor-progression: Percentage of Patients With Tumor Progression at 1 Year

Overall survival will be measured from the date of enrollment to date of death or last contact. Survival will be evaluated by the Kaplan Meier method to evaluate the median survival and 1 year survival rates.

Overall Survival: Percentage of Patients That Were Alive at 1 Year

The 3-day food diary will be used to assess the dietary intake and to increase eating awareness of patients.

Patients in the control arm receive oral cyanocobalamin (vitamin B 12) once a day for 6 months.
cyanocobalamin : 50 ug/day given orally

Food Intake as Assessed by the Block 98 Food Frequency Questionnaire and a 3-day Food Record

Overall Study

Dr. Glen Stevens

Brain and Central Nervous System Tumors

Cerebral Edema

Boswellia serrata extract

cyanocobalamin

Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center

Dietary, Herbal and Alternative Medicine in Glioblastoma Multiforme

Phase II Randomized Evaluation of 5-Lipoxygenase Inhibition by Herbal Complementary and Alternative Medicine Approach Compared to Control as an Adjuvant Therapy in Newly Diagnosed and Recurrent High-grade Gliomas

boswellia carteri/ödəm

Dietary, Herbal and Alternative Medicine in Glioblastoma Multiforme

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