Antibiotic 81-484 of the following physico-chemical properties:(1) elementary analysis: C.sub.33 H.sub.48 O.sub.7 (high resolution mass spectrum);(2) molecular weight: 556 [Field desorption (FD) mass spectrum];(3) melting point: not clear (oily at 10.degree.-100.degree. C.);(4) specific rotation: [.alpha.].sub.D.sup.20 =-151.degree. (c=0.1, methanol);(5) ultraviolet absorption spectrum: shown in FIG. 1 (in methanol);(6) infrared absorption spectrum: shown in FIG. 2 (KBr tablet);(7) solubility: insoluble in hexane and water, soluble in diethyl ether, methanol, ethanol, dichloromethane, chloroform, ethyl acetate, butyl acetate, acetone and benzene;(8) nuclear magnetic resonance spectrum: shown in FIG. 3 (CDCl.sub.3, TMS);(9) nature: acidic substance;(10) color reaction:negative for ninhydrin, anthrone-H.sub.2 SO.sub.4 and ferric chloride reaction;positive for iodine and antimony trichloride;weakly positive for Zatkis reagent;or a non-toxic salt thereof, is produced by culturing Streptomyces 81-484 FERM-P 7371 in a culture medium, and isolating the thus-produced antibiotic therefrom. The antibiotic has no antibiotic activity against Gram-positive and -negative bacteria, has antimicrobial activity against some kinds of fungi, and has growth inhibitory activity against P388 mouse leukemia cells and sarcoma 180 cells.

butyl acetate/dichloromethane

Antitumor antibiotic 81-484 and process for its production

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