12 nəticələr
Ependymomas account for 6-12% of all pediatric intracranial tumors. Despite complete resection and radiation, about 50% of patients relapse and have subsequent dismal prognoses. As no clinical findings reliably forecast tumor recurrence, we sought to determine if gene expression profiling could be
OBJECTIVE
Several genes have been shown to carry mutations in human malignant gliomas, including the phosphatase and tensin homolog (PTEN) deleted on chromosome 10 and p16 tumor suppressor genes. Alterations of this gene located on chromosome 10 q23 and 9p21, respectively, may contribute to
Calcineurin is one of the calmodulin binding proteins and a Ca2+-dependent and calmodulin-stimulated phosphoprotein phosphatase. We used antisera to the calcineurin as a cell-type-specific marker in order to identify neuronal cells in the rat brain and human neoplasms. In normal rat brain slices,
The classification of experimental brain tumours is essential for mutual understanding and for comparison with human CNS tumours. The histogenetic principle of human neurooncology should be applied to the classification of experimental tumours, too. In rats different quantities of experimental
Gliomas were induced transplancentally by the administration of ethylnitrosourea to pregnant rats on the 15th day of gestation. The fine structure of neurones involved in these tumours was studied in order to assess the changes caused by neoplasia. The severity of the neuronal damage depended on
Although two-thirds of tumors occurring in the central nervous system (CNS) are primary neoplasms, only 10% of positive cerebrospinal fluid (CSF) specimens are from primary CNS tumors. In this study, we reviewed the cytologic findings of 21 positive CSF specimens from primary CNS tumors. A computer
BACKGROUND
We report results of a phase I trial designed to estimate the maximum tolerated dose (MTD), describe dose-limiting toxicities (DLT), and characterize the pharmacokinetic profile of MK-2206, an AKT inhibitor, in children with refractory or recurrent malignancies.
METHODS
MK-2206 was
Double and triple immunocytochemical detection methods for routine use in histopathology were investigated. For double immunostaining, the combinations of immunogold-silver staining (IGSS, black) with an immunoperoxidase method (3-amino-9-ethylcarbazole, red-brown) or with an immunoalkaline
OBJECTIVE
This study evaluated the salivary biochemical and immunological status of children with cancer undergoing to antineoplasic treatment in an attempt to identify alternatives for a less invasive and less painful monitoring of these patients.
METHODS
Unstimulated whole saliva samples were
OBJECTIVE
To detect and analysis epidermal growth factor receptor (EGFR) and phosphatase and tensin homolog deleted on chromosome ten (PTEN) in different malignancy brain tumors, and to evaluate their prognostic significance.
METHODS
Using immunohistochemistry to detect the expression of EGFR and
Diaziquone (AZQ), a new lipid-soluble antitumor agent, was given by 15-30-minute infusion on a daily X 5 schedule to 47 children with refractory solid tumors and leukemia. The starting daily dose of 6 mg/m2 was escalated to 10 and 35 mg/m2 in patients with solid tumors and leukemia, respectively. In
BACKGROUND
Immunohistochemistry (IHC) has become an important tool in the diagnosis of brain tumors.
OBJECTIVE
To review the latest advances in IHC in the diagnostic neuro-oncologic pathology.
METHODS
Original research and review articles and the authors' personal experiences.
RESULTS
We review the