1st 2 weeks: gIFN 100 ugr/three times a week From the 3rd week: gIFN 200 ugr three times a week for the following 22 weeks From the 25th week: no treatment for the following 24 weeks

Friedreich Ataxia

1st two weeks: gIFN 100 ugr/three times a week from the 3rd week: gIFN 200 ugr/ three times a week for the following 22 weeks From the 25th week: no treatment for the following 24 weeks

gamma interferon

Open Trail of γIFN for Friedreich Ataxia

Safety and Efficacy of γIFN Treatment in Friedreich Ataxia

number of AE and SAE reported by treated patients along the study. Safety of γIFN treatment given for 6 months at final dose of 200 mcg three times weekly in FRDA patients

changes in scores at the SARA scale assessed at various time points (from 6 moths before treatment start to 6 months after treatment stop) for each patient

intensity of BOLD signal in FRDA patients performing the finger tapping protocol at least 6 months prior to treatment start, at treatmenet start, after 6 months of treatment and 6 months after treatment discontinuation

Mean Thickness of RNFL and thickness in the 4 quadrants as resulting from OCT exam

changes in ventricular and interventricular walls thickness (mm) at various time points for each patient

changes in Frataxin levels (intensity of frataxin band at western blot) associated with treatment

scores at SF36 assessed along time in each patient

Fractional anysotropy values at selected ROI as measured at various time points in each patient

friedreich ataxia/albumin

Open Trail of γIFN for Friedreich Ataxia

Elm tərəfindən dəstəklənən ən tam dərman bitkiləri bazası