Pregnancy with major fetal congenital heart disease, after 20 weeks gestation, and as neonate following delivery. Two fetal magnetocardiograms (fMCG) and 1 neonatal electrocardiogram (nECG) will be obtained and heart rate, rhythm, and conduction patterns will be compared.

Pregnancy with a history of an unexplained fetal demise (stillbirth at 20 -40 weeks gestation) during any prior pregnancy. Two fetal magnetocardiograms (fMCG) and 1 neonatal electrocardiogram (nECG) will be obtained and heart rate, rhythm, and conduction patterns will be compared.

Pregnancy with fetal hydrops, immune or non-immune, at or after 20 weeks gestation. Two fetal magnetocardiograms (fMCG) and 1 neonatal electrocardiogram (nECG) will be obtained and heart rate, rhythm, and conduction patterns will be compared.

Pregnancy with fetal gastroschisis, at or after 20 weeks gestation. Two fetal magnetocardiograms (fMCG) and 1 neonatal electrocardiogram (nECG) will be obtained and heart rate, rhythm, and conduction patterns will be compared.

Twin pregnancy, monochorionic, with or without twin-twin transfusion syndrome, at or after 20 weeks gestation. Two fetal magnetocardiograms (fMCG) and 1 neonatal electrocardiogram (fMCG) will be obtained and heart rate, rhythm, and conduction patterns will be compared.

High Risk Pregnancy

Congenital Heart Disease

Fetal Hydrops

Twin Monochorionic Monoamniotic Placenta

Gastroschisis

Fetal Demise

Stillbirth

Fetal Arrhythmia

Long QT Syndrome

Intrauterine Fetal Death

Sudden Infant Death

Pregnancy Loss

Twin Twin Transfusion Syndrome

Birth Defect

Fetal Cardiac Anomaly

Fetal Cardiac Disorder

Fetal Death

Brugada Syndrome

This study involves pregnant women and subsequently-born neonate(s) of either gender.

Fetal Magnetocardiography (fMCG) is a new non-invasive diagnostic procedure that records tiny fetal cardiac signals similar to an Electrocardiogram or Holter monitor. The magnetometer has FDA clearance, and does not emit magnetic, electric or other energies. This is not an MRI. Examples of fetal MCG's can be found in the Links. The American Heart Association Scientific Statement on Fetal Diagnosis and Treatment (Circulation, 2014) has declared fMCG to be Class IIa for fetal heart rhythm abnormalities, meaning that benefit far exceeds risk. As part of this study, a neonatal electrocardiogram (nECG) will be obtained for comparison after the baby is born.

Fetal Magnetocardiogram and Neonatal Electrocardiogram

Children's Hospital of Wisconsin Herma Heart Institute

University of Wisconsin - Madison

Medical College of Wisconsin

Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise

Fetal Electrophysiologic Abnormalities in High-risk Pregnancies Associated With Fetal Demise

To measure and compare the fMCG heart rate variability in five pregnancy conditions associated with fetal demise, to those of gestation matched normal fetuses.

To measure and compare the fMCG cardiac time intervals in five pregnancy conditions associated with fetal demise, to those of gestation matched normal fetuses and to neonatal ECG at 2 weeks of age.

To measure and compare the fMCG cardiac repolarization patterns in five pregnancy conditions associated with fetal demise, to those of gestation matched normal fetuses, and to neonatal ECG at 2 weeks of age.

2a) To determine whether unique "signature" electrophysiologic abnormalities are present in any of these five maternal-fetal diseases, and 2b) to define at what trimester these develop. Understanding any unique findings could allow study of specific treatment strategies in the future.
findings are first seen.

To correlate fMCG findings with 3a) outcomes of pregnancies (fetal demise, premature delivery, small for GA, 5 minute APGAR < 5, neonatal death) and 3b) fMCG cardiac time intervals with postnatal ECG intervals at 0-2 weeks of age.

gastroschisis/ödəm

Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise

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