Gelonin Purging of Autologous Stem Cells for Transplantation (ASCT) + Fludara/Busulfan

Acute Myelogenous Leukemia

Myelodysplastic Syndrome

Gelonin-AntiCD33 purging, 3 purging concentrations (fixed dose of 5 x 10^6 CD34+ cells/kg to be infused) with 3 dose levels of 1 nanomolar, 5.0 nanomolar and 10.0 nanomolar.

Gelonin

130 mg/m2 in normal saline over three (3) hours IV every twenty-four (24) hours for four (4) consecutive days (days -6 to -3).

Busulfan

40 mg/m2 in 100 ml of saline over one (1) hour on each of four (4) consecutive days (days - 6 to -3).

Fludarabine

UT MD Anderson Cancer Center

Study of Gelonin Purging of Autologous Stem Cells for Transplantation

Dose Finding Study of Gelonin Purging of Autologous Stem Cells for Transplantation of Patients With AML/MDS in First or Subsequent Remission

Dose-finding success, defined as patient alive and engrafted at day 28 post transplant, represented as number of patient successes with 3 differing doses (5, 10, or 15 nanomolar (nm) gelonin-antiCD33 purged autologous stem cells after a high dose fludarabine/busulfan conditioning regimen).

gelonin/leykoz

Study of Gelonin Purging of Autologous Stem Cells for Transplantation

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