The present invention concerns a compound of formula (I) ##STR1##wherein: W represents O or NH, Q represents an unbranched or branched, saturated or unsaturated or aromatic, cyclic or acyclic or heterocyclic hydrocarbon radical containing 1 to 30 carbon atoms including or not heteroatom(s), R.sup.1 is H, OH, or OMe, O-(C.sub.1 -C.sub.30)-alkyl, O-aryl-(C.sub.1 -C.sub.30)-alkyl, O-(C.sub.2 -C.sub.30)-alkenyl, O-(C.sub.3 -C.sub.30)-cycloalkyl or null, and R.sup.2 is H or OH, or R.sup.1 and R.sup.2 form together --O--, R.sup.3 =R.sup.4 =OMe or R.sup.3 and R.sup.4 form together --OCH.sub.2 O--, R is H, C.sub.1 -C.sub.30 alkyl or O-protecting group and R.sup.6 represents an unbranched or branched, saturated or unsaturated or aromatic, cyclic or acyclic or heterocyclic hydrocarbon radical containing 1 to 30 carbon atoms including or not heteroatom(s), or R and R.sup.6 form together --CMe.sub.2 --, n is 0 to 8, R.sup.5 is H, OH, OMe, O-(C.sub.1 -C.sub.30)-alkyl, O-aryl-(C.sub.1 -C.sub.30)-alkyl, O-(C.sub.2 -C.sub.30)-alkenyl, O-(C.sub.3 -C.sub.30)-cycloalkyl or O-aryl, the dotted line is null or forms a double bond depending on the meaning of R.sup.1.It also concerns their methods of preparation and their use in treatment of cancers, leukemias, parasites and as reversal agents of harringtonines.

Oncopharm Corporation

Cephalotaxanes: their method of preparation and their use in treatment of cancers, leukemias, parasites, including those resistant to usual chemotherapeutic agents, and as reversal agents

The present invention concerns a compound of formula (I) ##STR00001## wherein: W represents O or NH, Q represents an unbranched or branched, saturated or unsaturated or aromatic, cyclic or acyclic or heterocyclic hydrocarbon radical containing 1 to 30 carbon atoms including or not heteroatom(s), R.sup.1 is H, OH, or R.sup.1, R.sup.2 form together --O--, R.sup.3.dbd.R.sup.4.dbd.OMe or R.sup.3 and R.sup.4 form together --OCH.sub.2O--, R is H, C.sub.1-C.sub.30alkyl or O-protecting group and R.sup.6 represents an unbranched or branched, saturated or unsaturated or aromatic, cyclic or acyclic or heterocyclic hydrocarboned radical containing 1 to 30 carbon atoms including or not heteroatom(s), or R and R.sup.6 form together --CMe.sub.2-, n is 0 to 8, R.sup.5 is H, OH, OMe, O--(C.sub.1-C.sub.30)-alkyl, O-aryl-(C.sub.1-C.sub.30)-alkyl, O--(C.sub.2-C.sub.30)-alkenyl, O--(C.sub.3-C.sub.30)-cycloalkyl or O-aryl, the dotted line is null or forms a double bond depending on the meaning of R.sup.1. It also concerns their methods of preparation and their use in treatment of cancers, leukemias, parasites and as reversal agents of harringtonines.

Stragen Pharma S.A.

Cephalotaxanes, their method of preparation and their use in treatment of cancers, leukemias, parasites including those resistant to usual chemotherapeutic agents and as reversal agents

harringtonine/xərçəng xəstəliyi

Cephalotaxanes: their method of preparation and their use in treatment of cancers, leukemias, parasites, including those resistant to usual chemotherapeutic agents, and as reversal agents

Cephalotaxanes, their method of preparation and their use in treatment of cancers, leukemias, parasites including those resistant to usual chemotherapeutic agents and as reversal agents

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