Acupuncture for 30min [twice weekly for 8 weeks]

Chemotherapy-induced Peripheral Neuropathy

Acupuncture

Standard care

Prince of Wales Hospital

Queen Elizabeth Hospital

The Effectiveness and Cost-effectiveness of Acupuncture in Managing Chemotherapy-induced Peripheral Neuropathy

A Randomised Controlled Trial to Assess the Effectiveness and Cost-effectiveness of Acupuncture in the Management of Chemotherapy-induced Peripheral Neuropathy

measured using the Brief Pain Inventory which measures pain intensity and its interference with function.

The NCI-Common Toxicity Criteria (CTC) for Adverse Events is a physician based grading system that includes criteria and definitions for quantifying and grading CIPN (both neurosensory and neuromotor components). This grading scale comprises a sensory and motor assessment and utilises a 5-point scale ranging from grade 1 to grade 5.

The Total Neuropathy Score clinical version (TNSc). The TNS combines information obtained from grading of symptoms, signs, nerve conduction studies, and quantitative sensory tests, and provides a single measure to quantify neuropathy

Functional assessment of cancer therapy (FACT/GOG-Ntx) is a 38-item self reported questionnaire, divided into two sub-scales: the first one is a 27-item general assessment of quality of life sub-scale (FACT-G) while the second one is a 11-item neurotoxicity sub-scale. This tool demonstrated good internal reliability and construct validity

Sensory examination will take place by the doctor/nurse using 10-g monofilament to lightly touch the patient's hands and feet bilaterally with the patients eyes closed. The monofilament test is a standardised plastic filament that will be pressed against parts of the hands and feet. When the filament bends, its tip is exerting a pressure of 10-gr. Abnormal responses including hyperesthesia, anesthesia or hypoesthesia will be recorded.

We will explore the cost impact data and capture the frequency, type and extent of the costs of and service utilisation by patients. The cost analysis will be performed from the perspective of the health service provider and from a societal perspective. Included in the health care provider costs will be those accrued by the hospitals and general practitioners. Costs to the patients and their families, including social care, will be considered as the additional costs for society. Indirect costs in terms of workdays lost will also included. Data will be collected prospectively and retrospectively using a questionnaire designed by the University of Leeds.

Consumption of analgesics will also be measured with a patient diary, as well as the presence of other related symptoms (ie. fatigue, sleep, etc) using the 10-item Symptom Distress Scale

hyperesthesia/fatigue

The Effectiveness and Cost-effectiveness of Acupuncture in Managing Chemotherapy-induced Peripheral Neuropathy

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