Cerebral Arteriovenous Malformation

Department of Neurosurgery, Medical University of Vienna

Evaluation of Nidus Occlusion After Gamma Knife Radiosurgery of Cerebral Arteriovenous Malformations Using Magnetic Resonance Imaging

MRI Evaluation of Nidus Occlusion After Gamma Knife Radiosurgery of Cerebral Arteriovenous Malformations - A Prospective Preliminary Study

Sensitivity and specificity of MRI/MRA evaluated by catheter angiography

Reference method for evaluation of sensitivity and specificity of MRI/MRA

Josa M Frischer, MD, PhD

Assoc.Prof.Priv.Doz.Dr.PhD

Medical University of Vienna

Medical Scientific Fund of the Mayor of Vienna

Interventional therapies include:
neurosurgery (surgical resection when the lesion is considered by a multidisciplinary team to be safely 'operable'); radiation therapy (when the AVM is smaller than 3 cm, and considered to not be safely 'operable'); radiosurgery, alone or in combination, with or without endovascular procedure; curative embolization (when the lesion is considered curable by embolization).
Patients with AVMs that the multidisciplinary team judges could potentially benefit from endovascular treatment prior to surgical resection or radiation therapy will then also be pre-randomly allocated to embolization or to no embolization.

The conservative, or medical management arm, involves pharmacological therapy as deemed appropriate for medical symptoms as determined by the treating investigator. Should patients in the conservative management arm develop hemorrhage or infarction related to their AVM, they then potentially become candidates for interventional therapy.

Unruptured Brain Arteriovenous Malformation

Ruptured Brain Arteriovenous Malformation

Arteriovenous Malformations

BAVM

Surgical resection to be used when the lesion is considered by a multidisciplinary team to be safely 'operable'.

Neurosurgery

when the AVM is smaller than 3 cm, and considered to not be safely 'operable'.

Radiation therapy

Curative embolization, when the lesion is considered curable by embolization.

Embolization

Mayo Clinic in Jacksonville FL

Boston Medical Center

University of New Mexico Health Sciences Center

Centre Hospitalier de l'Université de Montréal

CHRU de Brest (Brest University Hospital)

Centre Hospit Régional Universitaire de Besançon

Centre Hospitalier Universitaire de Bordeaux

Centre Hospitalier Universitaire de Caen

CHU Clermont-Ferrand

CHU Dijon Bourgogne

Hôpital Bicêtre AP-HP

CHU Limoges

Centre Hospitalier Universitaire de Lyon

Assistance Publique - Hôpitaux de Marseille

Centre Hospitalier Universitaire de Montpellier

Centre Hospitalier Régional Universitaire de Nancy

Centre Hospitalier Universitaire de Nantes

Hôpital Universitaire Pitié-Salpêtrière

Fondation Ophtalmologique Rothschild

Centre Hospitalier Sainte-Anne

Centre Hospitalier Universitaire de Rennes

Centre Hospitalier Universitaire Hôpitaux de Rouen

Les Hôpitaux Universitaires de Strasbourg

Centre Hospitalier Universitaire de Toulouse

Centre Hospitalier Régional Universitaire de Tours

Treatment of Brain AVMs (TOBAS) Study

Treatment of Brain AVMs (TOBAS) Study: A Randomized Controlled Trial and Registry

death or disabling stroke due to hemorrhage or infarction as revealed by imaging and resulting in mRS >2.

The incidence of permanent (more than 3 months) disabling (mRS >2) peri-operative (within 31 days) complications

intracranial arteriovenous malformations/seizures

Evaluation of Nidus Occlusion After Gamma Knife Radiosurgery of Cerebral Arteriovenous Malformations Using Magnetic Resonance Imaging

Treatment of Brain AVMs (TOBAS) Study

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