Treatment with dexlansoprazole 60 mg once daily for 3 months

Laryngopharyngeal Reflux

Hypertrophy of Lingual Tonsil

dexlansoprazole 60 mg once daily for 3 months

dexlansoprazole

Advanced Center for Specialty Care

Dexlansoprazole to Treat Laryngopharyngeal Reflux and Lingual Tonsil Hypertrophy

A Randomized, Double-blind, Placebo-controlled Study of Dexlansoprazole to Treat Laryngopharyngeal Reflux and Lingual Tonsil Hypertrophy

Lingual tonsil tissue size will be measured on computed tomography image at baseline and remeasured following CT imaging after 3 months of proton pump inhibitor therapy.

Calgary Sleep Apnea Quality of Life Index measures the quality of life in sleep apnea patients.

Visual Analog Scale of snoring measures the loudness and disturbance factor related to snoring as documented by the bedpartner (when available)

Epworth Sleepiness scale measures the daytime sleepiness caused by sleep disturbances and interruptions associated with sleep apnea or snoring.

Reflux Symptom Index monitrors the physical signs and symptoms of laryngopharyngeal reflux during treatment obtained during fiberoptic endoscopy of the larynx, pharynx and esophagus.

Continuous 24 hour laryngopharyngeal pH monitoring

Michael Friedman, MD

Takeda

Patients who have documented GERD as evidenced by erosive esophagitis or those patients who have newly diagnosed laryngopharyngeal reflux as diagnosed by endoscopy.

Patients who have documented GERD as evidenced by erosive esophagitis or those patients who have newly diagnosed laryngopharyngeal reflux as diagnosed by endoscopy.
Prevacid: 30 mg bid for 3 months
Esophageal and Laryngeal Biopsies: repeat egd with biopsy

Patients Receiving Prevacid

Sex: Female, Male

Region of Enrollment

Dilation of inter cellular spaces (the space within the cell) is reported to be an early morphological (structure and form) marker in gastro-oesophageal reflux. Using electron microscopy, the distance between epithelial cells is quantified.

Number of Patients With Dilation of Intracellular Spaces 3 Months After Therapy

Overall Study

Dr. Michael Vaezi

Larynx Disease

Gastroesophageal Reflux

Prevacid

repeat egd with biopsy after Prevacid 30 mg bid for 3 months

laryngopharyngeal reflux/ödəm

Dexlansoprazole to Treat Laryngopharyngeal Reflux and Lingual Tonsil Hypertrophy

Do Laryngeal Tissue Changes in Patients Suspected of Having Laryngopharyngeal Reflux Predict Response to Treatment?

Esophageal and Laryngeal Tissue Changes in Patients Suspected of Having Laryngopharyngeal Reflux

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