Subjects will rinse twice daily with 15 ml mouthrinse containing Chlorhexidine gluconate (0.12%).

Subjects will rinse twice daily with 15 ml mouthrinse containing nanoparticles of M. alternifolia oil (0.3%).

Dental Plaque

At baseline, subjects will receive a professional prophylaxis and will be instructed to withdrawal oral hygiene methods for 3 days. At day 4, 2 contra-lateral quadrants will be randomly chosen to receive a professional prophylaxis, being controls for plaque-covered surfaces. Subjects will then start to rinse twice daily with 15 ml mouthrinse containing Chlorhexidine gluconate (0.12%). Plaque indices will be recorded at baseline, day 4, and day 7.

Chlorhexidine gluconate 0.12% (PerioGard®)

At baseline, subjects will receive a professional prophylaxis and will be instructed to withdrawal oral hygiene methods for 3 days. At day 4, 2 contra-lateral quadrants will be randomly chosen to receive a professional prophylaxis, being controls for plaque-covered surfaces. Subjects will then start to rinse twice daily with 15 ml mouthrinse containing a nanoparticle solution of M. alternifolia oil (0.3%). Plaque indices will be recorded at baseline, day 4, and day 7.

Nanoparticle solution of M. alternifolia oil (0.3%).

Effect of Different Mouthrinses in Plaque Formation

Anti-plaque Effect of 0.12% Chlorhexidine Gluconate Rinsing and Nanoparticle Solution of 0.3% Melaleuca Alternifolia: A Randomized Crossover Clinical Trial

The volume of gingival fluid will be measured at two locations per quadrant.

Maísa Casarin

MsC, Federal University of Santa Maria

Universidade Federal de Santa Maria

Centro Universitário Franciscano

Pea-sized amount of tea tree oil medicated gel (containing 200mg/g tea tree oil) applied to the face twice daily for 12 weeks.

Acne

Tea tree oil

Royal Perth Hospital

Hollywood Private Hospital

Pilot Study to Evaluate Tea Tree Oil Gel for Facial Acne

Uncontrolled, Open-label, Phase II Pilot Study to Evaluate the Efficacy, Tolerability and Acceptability of 200mg/g Tea Tree Oil Gel Applied Topically Twice Daily for the Treatment of Mild to Moderate Facial Acne

Numbers of inflamed and non-inflamed facial lesions will be counted.

A 5-point severity scale (0-4) will be used to give an overall acne grade.
0: Clear skin with no lesions
Almost clear; rare lesions
Mild severity; some non-inflammatory lesions with no more than a few inflammatory lesions
Moderate severity; up to many non-inflammatory lesions and may have some inflammatory lesions
Severe; up to many noninflammatory and inflammatory lesions but no more than a few nodular lesions

Decrease in numbers of non-inflammatory lesions from baseline

Decrease in inflammatory lesion count from baseline

Decrease in perceived facial oiliness from baseline

Mean tolerability will be determined as the average of the following;
Erythema
Scaling
Peeling
Burning
Induration
Dryness
These six parameters will be measured using a 5-point scale (0: None, 1: Minimal, 2: Mild, 3: Moderate, 4: Severe). Mean tolerability will be the average of these scores.

Any local or systemic adverse events will be recorded including the type of reaction and severity (on a 5-point severity scale where 0 = none and 4 = severe).

melaleuca alternifolia/antiinflamatuar

Effect of Different Mouthrinses in Plaque Formation

Pilot Study to Evaluate Tea Tree Oil Gel for Facial Acne

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