Arm A will Tranexamic Acid 1g iv bolus as loading dose followed by 3g Tranexamic Acid infused over next 24 hours along with standard medical and interventional (Endoscopy) therapy.

Arm B will receive similar volume of isotonic solution (saline) along with standard medical and interventional (Endoscopy) therapy.

Liver Cirrhosis

Tranexamic Acid 1g iv bolus as loading dose followed by 3g Tranexamic Acid infused over next 24 hours

Tranexamic acid

Standard Medical Treatment

Placebo

Institute of Liver & Biliary Sciences

Tranexamic Acid for Acute Upper Gastrointestinal Bleed in Cirrhosis

Tranexamic Acid for Acute Upper Gastrointestinal Bleed in Cirrhosis - A Randomized Placebo Controlled Trial

Clinically significant rebleed as monitored by hemoglobin drop by 3g/dl, need of blood transfusion

Institute of Liver and Biliary Sciences, India

The active control group is stimulated with: Output current 0.25 milliampere, Pulse width 0.1 milliseconds, Frequency 1 Hz, Duty cycle: 14 sec on 60 min off (duty cycle <0.5%)

The high stimulation group is stimulated with output current 0.25 milliampere, Pulse width 0.5 milliseconds, Frequency 30 Hz, Duty cycle: 30 sec on 5 min off in the treatment group the current was stepwise increased with two week intervals to the maximally tolerated output current (maximum 1.75 mA).

Refractory Epilepsy in Children

The study group is stimulated with the following parameters: Output current 0.25 milliampere (to be ramped up to max. 1.75 milliampere), Pulse width 0.5 milliseconds, Frequency 30 Hz, Duty cycle: 30 sec on 5 min off (duty cycle 10%).

Vagus Nerve Stimulator: Neurocybernetic prothesis NCP, Cyberonics Inc., Webster, TX, USA

Maastricht University Medical Center

Epilepsiecentrum Kempenhaeghe

Does VNS Interact With the Serotonergic and Immune System in Children With Intractable Epilepsy?

Does VNS Interact With the Serotonergic and Immune System in Children With Intractable Epilepsy? A Randomized Clinical Study.

Seizure frequency is measured by using seizure diaries

noradrenalin/seizures

Tranexamic Acid for Acute Upper Gastrointestinal Bleed in Cirrhosis

Does VNS Interact With the Serotonergic and Immune System in Children With Intractable Epilepsy?

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