Dexamethasone 8 mg pre-operative
Dexamethasone: pre-operative intravenous administration

Dexamethasone 8 mg

Dexamethasone 24 mg pre-operative
Dexamethasone: pre-operative intravenous administration

Dexamethasone 24 mg

Total

Sex: Female, Male

Race and Ethnicity Not Collected

Number of patients meeting criteria for transfer to PACU post-surgery

Transfer to Post-anesthesia Care Unit (PACU)

Danish Society of Anesthesiology and Intensive Care Medicine (DASAIM) discharge score.Construct: The score consists of six modalities (subscores): Sedation,Oxygen saturation,blood pressure,heart rate,pain (at rest)and nausea.Each modality has a score between 0 and 3,and patients are considered dischargeable to the ward when the score sum of all criteria (total score) is 4 or less and no single score is above 1. All values (subscores) are considered best at 0 and worst at 3.
Sedation: 0 fully awake, 1, sleeping aroused by verbal stimuli, 2 sleeping aroused by physical stimuli, 3 sleeping cannot be aroused.
Oxygen saturation (%):0 ≥94, 1 90-93, 2 85-89, 3 <85. Blood pressure, systolic (mmHg): 0 100-220, 1 90-99. 2 80-89 or >220, 3<80. Heart rate; pr. min: 0 50-100, 1 101-120, 2 40-49 or 121-130, 3 <40 or >130. Pain (at rest) (Numeric rating scale 0-10): 0 0, 1 0-2, 2 3-6, 3 ≥ 7 Nausea (patient evaluation and nurse observation): 0 none, 1 light, 2 moderate, 3 severe or vomiting.

Discharge Score,(Modified Aldrete Discharge Score), Operating Room

DASAIM score (Danish Society of Anesthesiology and Intensive Care Medicine). The score consists of six modalities: Sedation, Oxygen saturation, blood pressure, heart rate, pain (at rest) and nausea.
Each modality has a score between 0 and 3, and patients are considered dischargeable to the ward when the score sum of all criteria is four or less and no single score is above one.
Sedation: 0 fully awake, 1, sleeping aroused by verbal stimuli, 2 sleeping, aroused by physical stimuli, 3 sleeping, cannot be aroused.
Oxygen saturation (%): 0 ≥ 94, 1 90-93, 2 85-89, 3 <85. Blood pressure, systolic (mmHg): 0 100-220, 1 90-99. 2 80-89 or >220, 3<80. Heart rate; pr. min: 0 50-100, 1 101-120, 2 40-49 or 121-130, 3 <40 or >130. Pain (at rest) (Numeric rating scale 0-10): 0 0, 1 0-2, 2 3-6, 3 ≥ 7 Nausea (patient evaluation and nurse observation): 0 none, 1 light, 2 moderate, 3 severe or vomiting.

Discharge Score, Arrival at PACU

Discharge Score, Arrival at Ward

complications requiring treatment until discharge

Number of Participants With Complication

Length of stay in the post-anesthesia care unit (PACU), measured as hours and minutes, from start of procedure, to discharge from PACU

Total Length of Stay in PACU

Length of stay in hospital, measured from start of procedure to discharge from hospital to home

Total Length of Stay in Hospital

Secondary transfer to PACU from ward, or to intensive care unit from PACU

Secondary Transfer

Self-reported pain (worst and average (average through that day), days 0-4) on a numeric rating scale (NRS) 0-10. 0 is no pain, 10 is worst pain imaginable.. Questionnaire.

Pain, Numeric Rating Scale

Self-reported nausea, questionnaire, day 0-4. Number of participants reporting nausea and/or vomiting

Post Operative Nausea and Vomiting (PONV).

Self-reported quality of sleep (days 0-4). Questionnaire. Dichotomized to Good sleep or sleep problems, numbers reported are number of patients with sleep problems

Quality of Sleep

Self-reported feelings of restlessness, sadness and fatigue (days 0-4). Questionnaire (anwers possible: yes or no. Numbers are patients answering yes)

Mental Status

Seroma, requiring treatment the first 14 days.

Number of Participants With Seroma, Requiring Treatment

Readmission

Overall Study

kristin steinthorsdottir, md

Dexamethasone

Glucocorticoids

Mastectomy

Breast Cancer

Pain, Postoperative

Nausea and Vomiting, Postoperative

Steroid

Systemic Inflammatory Response Syndrome

Postoperative Complications

Rigshospitalet

High vs Low Dose Dexamethasone on Complications in the Immediate Postoperative Phase After Mastectomy

Effect of High vs Low Dose Intravenous Dexamethasone on Complications in the Immediate Postoperative Phase After Mastectomy- a Randomized, Double-blind, Controlled Trial

Kristin Julia Steinthorsdottir

Principal investigator, MD, Clinical assistant

Rigshospitalet, Denmark

Chronic Visceral Pain patients. Participants will be tested before and after implantation of a Spinal Cord Stimulator (implantation of the Spinal Cord Stimulator is done as usual care and is not a study procedure)

Chronic Pain

Orthostatic vital signs will be determined by measuring heart rate (HR) and brachial blood pressure (BP) during a tilt table test. The degree of vagal mediated sinus arrhythmia will be assessed during controlled breathing (5 seconds inhalation and 5 seconds exhalation during 90 seconds), and the sinus arrhythmia parameters will be calculated as the difference and ratio of the longest to the shortest RR interval. The sympathetic response during breath hold will be measured. Responses of BP, HR, MSNA will be acquired during Valsalva maneuver. The valsalva ratio of heart rate will be calculated from the maximum of heart rate during or shortly after straining and the minimal depressed heart rate in the overshoot phase IV. Blood pressure and MSNA increase during isometric handgrip maintained at 30% of maximal voluntary contraction for five minutes will be determined. The blood pressure and MSNA response will be measured during cold pressor test with the hand in ice water for 1 minute.

Autonomic Evaluation

Interventional Pain Center

Microneurography and Spinal Cord Stimulation in Chronic Visceral Pain

Autonomic Function Testing and Spinal Cord Stimulation: Implications for Successful Therapy in Chronic Visceral Pain

Microneurography directly assesses muscle sympathetic nerve activity (MSNA)

Participants in both arms will be tested at baseline and again within 1 year. Participants in the Chronic Visceral Pain arm will be tested after implantation of a Spinal Cord Stimulator

orthostatic intolerance/xərçəng xəstəliyi

High vs Low Dose Dexamethasone on Complications in the Immediate Postoperative Phase After Mastectomy

Microneurography and Spinal Cord Stimulation in Chronic Visceral Pain

Elm tərəfindən dəstəklənən ən tam dərman bitkiləri bazası