Periodontitis

SRP+ 10% Emblica officinalis irrigation

SRP + 0.2% Chlorhexidine irrigation)

SRP + 0.9% Saline irrigation

SRP +10% E. officinalis gel application.

SRP+ placebo gel application.

Post Graduate Institute of Dental Sciences

Emblica Officinalis Irrigation in Periodontitis

Effect of Emblica Officinalis (Amla) as an Adjunct to Scaling and Root Planing in Patients With Chronic Periodontitis

Postgraduate Institute of Dental Sciences Rohtak

Phyllanthus niruri 3g fine dry powder 3 times a day with warm water before meals for 8 weeks
Sida cordifolia 7g coarse dry powder 2 times a day prepared as traditional decoction before meals for 8 weeks. Decoction: Take provided measurement cup full of water (112ml) and soak one portion (pe-packed) of the powder for 12 hours, then boil it until the upper level has been reduced to 1/4, filter, cool down to room temperature, drink

Phyllanthus niruri extract 2 capsules 3 times a day with warm water before meals for 8 weeks
Sida cordifolia roots extract 2 capsules 2 times a day with warm water before meals for 8 weeks

Phyllanthus niruri placebo 2 capsules 3 times a day with warm water before meals for 3 weeks
Sida cordifolia placebo 2 capsules 2 times a day with warm water before meals for 3 weeks

Diabetic Polyneuropathy

Diabetic Neuralgia

Diabetic Neuropathies

Diabetic Neuropathy

Sida cordifolia roots, crude drug (coarse powder) a plant product 7g (packages prepared) are soaked in 112ml water (measurement cup provided) for 12 hours and then boiled until the level is reduced to 1/4 of hight. Fluid is filtered an drunk after cooling down to room temperature - orally 2 times a day before breakfast and dinner

Sida cordifolia roots

Phyllanthus niruri (whole plant) fine powder 3g three times a day with warm water before meals taken orally.

Phyllanthus niruri

gelatine capsule with 300mg Sida cordifolia roots spraydry extract 12:1 concentrated normalized to alkaloids (alcoholic/aqueous extract) - 2 capsules taken orally 2 times a day with warm water before meal

Sida cordifolia roots extract

gelatine capsule with 300mg Phyllanthus niruri spray dry extract 5:1 concentrated normalized to bitters (alcohol/aqueous extract) - 2 capsules taken orally 3 times a day with warm water before meal

Phyllanthus niruri extract

300mg inert Maltodextrin in gelatine capsule. 2 capsules given 2 times a day orally with warm water before meals

Sida cordifolia placebo

300mg inert Maltodextrin in gelatine capsule. 2 capsules given 3 times a day orally with warm water before meals

Phyllanthus niruri placebo

Nadiad Ayurveda College and Hospital - Site of study

Sponsor - Rosenberg European Academy of Ayurveda

Funding society: European Professional Association of Ayurveda-Practitioners and -Therapists

P.D. Patel Ayurveda Hospital

A Study of Phyllanthus Niruri and Sida Cordifolia in Diabetic Peripheral Polyneuropathy

A Randomized Placebo-compared Study on Efficiency of Two Different Administration Forms of Phyllanthus Niruri and Sida Cordifolia in Patients With Diabetic Peripheral Polyneuropathy

Validated symptom score containing 6 questions investigation severity (not present, mild, moderate, severe) and frequency (never or occasional, occasional but normal, often, almost continuous) of symptoms (aching pain, allodynia, burning pain, lancinating pain, numbness, prickling sensation).

Semi-automated Neuropathy Analyser Dx from Diabetic Footcare India used to detect vibration and thermal (hot/cold) threshold (both soles)
Inability to feel vibration up to: Normal: 10Hz below age of 50a and 15Hz above age of 50a = scoring "0"; Mild: 11-15Hz below age of 50a and 16-20Hz above age of 50a = scoring "1"; Moderate: 16-20Hz below age of 50a and 21-25Hz above age of 50a = scoring "2"; Severe: 20Hz below age of 50a and 26Hz above age of 50a = scoring "3"
Inability to feel cold down to: Normal: 20°C = scoring "0"; Mild: 19-15°C = scoring "1"; Moderate: 14-10°C = scoring "2"; Severe: < 9°C = scoring "3"
Inability to feel hot up to: Normal: 42°C = scoring "0"; Mild: 43-45°C = scoring "1"; Moderate: 46-48°C = scoring "2"; Severe: > 49°C = scoring "3"
Temperature of the probe is to be reduced from 30°C to 0°C to record perception of cold sensation and temperature of the probe is to be increased from 30°C up to 50°C to record perception of heat sensations.

The used questionaire is an adaption of the warfarin compliance-assessment scale from Community Anticoagulation Therapy Clinic in Iowa. (Huber, Levett, & Atkinson, 2008)
Medication - Missed doses:
No dose missed = score "0"
One dose in a week missed = score "1"
Two doses in a week missed = score "2"
Three or more doses missed = score "3"
Medication - Additional doses:
No extra dose = score "0"
One extra dose = score "1"
Two extra doses = score "2"
Three or more extra doses in a week = score "3"
Food habits:
Completely followed dietary recommendations = score "0"
One day a week I ignored dietary recommendations = score "1"
Two days a week I ignored dietary recommendations = score "2"
Three or more days a week I ignored recommendations = score "3"

With every distributed one-week-package of drug/placebo the patients will get a diary where they are supposed to fill in if medication has been taken (morning/lunch/dinner) and how there symptoms are like (non, mild, moderate, severe) for every single day.

phyllanthus phillyreifolius/mantar

Emblica Officinalis Irrigation in Periodontitis

A Study of Phyllanthus Niruri and Sida Cordifolia in Diabetic Peripheral Polyneuropathy

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