Patients undergoing EGD with ePFT for symptoms of suspected or known pancreatic insufficiency.

Patients undergoing diagnostic EGD that consent to undergo ePFT.

Abdominal Pain

Irritable Bowel Syndrome

Secretin is a gastrointestinal peptide hormone, indicated for the stimulation of: pancreatic secretions, including bicarbonate, to aid in the diagnosis of pancreatic exocrine dysfunction.

synthetic human secretin

Recurrent Abdominal Pain and Exocrine Pancreatic Insufficiency

Secretin stimulated exocrine pancreatic enzyme activity will be measured in patients with abdominal pain who are undergoing upper endoscopy to identify those with insufficiency (EPI).

This includes immunological and genetic markers.

Devendra Mehta

Director, Pediatric Gastroenterology Laboratory, Arnold Palmer Hospital for Children

Orlando Health, Inc.

ChiRhoClin, Inc.

Exocrine Pancreatic Insufficiency

The diagnosis of EPI will be made through the combination of two diagnostic tests.
The labeled triolein breath test will use criteria established by the manufacturer of the product (Pancreo-Kit®) Isomed pharma.
The fecal elastase test will be performed at our own center (Bioserv Diagnostics (BS-86-01 Elastase Pancreatic ELISA) distributed by Palex Medical.) In those cases where both results are negative, it will be considered that there is no EPI. In cases where both results are positive, the diagnosis of EPI will be performed. If the results are discordant, a Sobel test or feces quantification test will be performed.

Labeled triolein urea breath test

Prevalence of Exocrine Pancreatic Insufficiency in Patients With Decompensated Cirrhosis

The diagnosis of EPI will be made through the combination of two diagnostic tests.
The labeled triolein breath test will use criteria established by the manufacturer of the product (Pancreo-Kit®) Isomed pharma.
Reference value: Normal: > 29%; Pathological: < 29% of the fat administered
The fecal elastase test (Bioserv Diagnostics (BS-86-01 Elastase Pancreatic ELISA) distributed by Palex Medical.)
A normal result will be considered: 200 to > 500 μg / g
Slight exocrine pancreatic insufficiency- Moderate: 100 - 200 μg / g
Severe exocrine pancreatic insufficiency: <100 μg / g
In those cases where both results are negative, it will be considered that there is no EPI. In cases where both results are positive, the diagnosis of EPI will be performed. If the results are discordant, a Sobel test or feces quantification test will be performed.
Coefficient of fat absorption; Pathological if elimination > 7g of fat / day with a diet of 100g fat / day.

Jordi Sanchez-Delgado

M.D; PhD

Corporacion Parc Tauli

Establish the advantage of combined EUS, ePFT & sEUS testing to provide a more definitive diagnostic assessment, rather than each test alone.
Establish the advantage of reduced time and cost of combining EUS and ePFT, rather than when done separately.

Pancreatic Disease

advantage of combined EUS, ePFT & sEUS testing to provide a more definitive diagnostic assessment, rather than each test alone.
Establish the advantage of reduced time and cost of combining EUS and ePFT, rather than when done separately.

Combined EUS, e-PFT and sEUS Testing

Indiana University; University Hospital

EUS Ductal Evaluation in One Endoscopic Session for the Diagnosis of Exocrine Pancreas Disease

Evaluation of Combined Endoscopic Ultrasound Ductal Evaluation Before & After Secretin Stimulation in One EUS Session for the Diagnosis of Exocrine Pancreas Disease

Combined Endoscopic Ultrasound Morphologic Evaluation, Endoscopic Pancreatic Function Testing, and Dynamic EUS Ductal Evaluation before and after Human Secretin Stimulation in one Endoscopic Session for the Diagnosis of Exocrine Pancreas Disease

Establish the advantage of combining EUS and ePFT to provide a more definitive diagnostic assessment, rather than each test alone.
Establish the advantage of reduced time and cost of combining EUS and ePFT, rather than when done separately.

secretin/diarreya

Recurrent Abdominal Pain and Exocrine Pancreatic Insufficiency

Prevalence of Exocrine Pancreatic Insufficiency in Patients With Decompensated Cirrhosis

EUS Ductal Evaluation in One Endoscopic Session for the Diagnosis of Exocrine Pancreas Disease

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