DNA samples will be stored in an appropriate place recognizable by inscriptions or encodings that will in any way be attributable to any personal or sensitive data of the patient in full respect of privacy, and will be accessible only by the staff involved in the study in full compliance with the safety standards.

Tuberculosis, Pulmonary

Ospedale Amedeo di Savoia

Personalization of AntiTB Treatment: Evaluation of Pharmacological Determinants of Treatment Response

Investigate the correlation of plasma drug concentrations (Rifampicin, Isoniazid, Ethambutol and Pyrazinamide, HRZE) with the change in Time To Positivity (TTP) in liquid culture in patients with active pulmonary TB between the baseline and the first week of treatment.

Investigate the correlation of plasma drug concentrations (Rifampicin, Isoniazid, Ethambutol and Pyrazinamide, HRZE) with the change in Time To Positivity (TTP) in liquid culture in patients with active pulmonary TB between the baseline and the second week of treatment.

Investigate the correlation of plasma drug concentrations (Rifampicin, Isoniazid, Ethambutol and Pyrazinamide, HRZE) with hepatotoxicity (increase of AST and/or ALT) and neurotoxicity (peripheral neuropathy)

Investigate the impact of different allelic variants of NAT2, SLCO1B1, ABCB1, VDR on AUC of RHZE toxicity and TTP in liquid culture

Assess the consistency of using dried plasma spots to measure plasma concentrations of anti-TB drugs comparing to plasma samples

A pharmacometric model will be develop to correlate pharmacokinetics (AUC of RHZE) with the anti-TB treatment response (clinical and TTP) of the standard first-line anti-TB regimen.

A pharmacometric model will be develop to correlate PG with the anti-TB treatment response (clinical and TTP) of the standard first-line anti-TB regimen.

Ilaria Motta

Principal Investigator

University of Turin, Italy

Research Center Borstel

Exercise Training

12 weeks of training by Professional Golf Association professional

golf training

University Southern California

West Los Angeles Veterans Administration

Golf for Veterans Study

Golf Intervention for Veterans Exercise Study

Change in National Institute of Health Toolbox Fluid Cognition Composite Score Fully-corrected T Score metric normative mean of 50 and an SD of 10. Range is 0-100. Higher scores reflect better outcomes.
The Fluid Cognition Composite Score is comprised of 5 subscales Dimensional Change Card Sort Test (measures executive function) Flanker Inhibitory Control and Attention Test measures attention and executive function Picture Sequence Memory Test (measures episodic memory) List Sorting Working Memory Test (measures working memory) Pattern Comparison Test (measures processing speed) Composite score is derived by averaging the standard scores of each of the five subscales. All subscales scores the same T-score metric

George Salem

Associate Professor

University of Southern California

Non-golfers instructed to golf over 10 weeks

Golf instruction

Golf for Healthy Aging

Golf Intervention for Healthy Aging Study

Royal & Ancient Group

The infected individuals were treated with the standard chloroquine (CQ)+primaquine(PQ) regimen to malaria caused by Plasmodium vivax.
Chloroquine (tablet containing 150mg of base) - it was given on days 0 (10mg/kg), 1 (7.5mg/kg) and 2 (7.5mg/kg). Total dose, 25 mg base/kg.
Primaquine - it was given once a day (0.5 mg/kg) for seven days, starting on day 0 of CQ treatment. Total dose, 3.5mg/kg The medications were administered under direct observation and the patient was monitored for vomiting for 60 minutes.

The infected individuals were initially treated with chloroquine (CQ) alone and the primaquine(PQ) was introduced on day 28.
Chloroquine (tablet containing 150mg of base) - it was given on days 0 (10mg/kg), 1 (7.5mg/kg) and 2 (7.5mg/kg). Total dose, 25 mg base/kg.
Primaquine - it was given once a day (0.5 mg/kg) for seven days, starting on day 28 of CQ treatment. Total dose, 3.5mg/kg.
The medications were administered under direct observation and the patient was monitored for vomiting for 60 minutes.

Malaria, Vivax

10mg/kg on day 0 and 7.5mg/kg on days 1 and 2. Total dose, 25 mg base/kg. Tablet containing 150mg of base.

Chloroquine

0.5 mg/kg once a day, for seven days. Total dose, 3.5mg/kg.

Primaquine

Oswaldo Cruz Foundation

Institute of Biomedical Sciences, University of Sao Paulo

Efficacy of Chloroquine (CQ) Alone Compared to Concomitant CQ and Primaquine for Plasmodium Vivax Infection

Efficacy of Chloroquine (CQ) Alone Compared to Concomitant CQ and Primaquine (PQ) for the Treatment of Uncomplicated Plasmodium Vivax Infection

danger signs or severe malaria on day 1, 2 or 3 in the presence of parasitaemia OR parasitaemia on day 2 higher than on day 0 OR parasitaemia on day 3 with axillary temperature ≥ 37.5 ºC OR parasitaemia on day 3 ≥ 25% of count on day 0

danger signs or severe malaria in the presence of parasitaemia on any day between day 4 and day 28 OR parasitaemia on any day between day 4 and day 28 with axillary temperature ≥ 37.5 ºC (or history of fever) in patients who did not previously meet any of the criteria of early treatment failure

presence of parasitaemia on any day between day 7 and day 28 with axillary temperature < 37.5 ºC in patients who did not previously meet any of the criteria of early treatment failure or late clinical failure

Any unfavourable and unintended sign (including an abnormal laboratory finding), symptom or disease temporally associated with the use of the study medication, whether or not considered related to the study medication.

Any untoward and unintended responses to a medicinal product related to any dose judged by either the reporting medically qualified professional or the sponsor as having a reasonable suspected causal relationship to the study medication.

spotted/mantar

Personalization of AntiTB Treatment: Evaluation of Pharmacological Determinants of Treatment Response

Golf for Veterans Study

Golf for Healthy Aging

Efficacy of Chloroquine (CQ) Alone Compared to Concomitant CQ and Primaquine for Plasmodium Vivax Infection

Elm tərəfindən dəstəklənən ən tam dərman bitkiləri bazası