An azole derivative represented by the following general formula (I) ##STR1## (symbols in the formula have the following meanings; R.sup.1 and R.sup.2 : the same or different from each other and each represents a hydrogen atom, a lower alkyl group or a phenyl group which may be substituted with a halogen atom,A, B and D: the same or different from one another and each represents a group represented by the formula ##STR2## or a nitrogen atom,X and Y: the same or different from each other and each represents a single bond, a methylene group, an oxygen atom,a group represented by a formula S(O).sub.n, or a group represented by the formula ##STR3## R.sup.3 and R.sup.4 : the same or different from each other and each represents a hydrogen atom or a lower alkyl group, andn: 0, 1 or 2),a salt thereof, a hydrate thereof or a solvate thereof.This compound has a function to inhibit steroid 17-20 lyase and is useful as preventive and treating agents for prostatic cancer, prostatic hypertrophy, virilism, breast cancer, mastopathy, histeromyoma, and endometriosis.

Yamanouchi Pharmaceutical Co., Ltd.

Azole derivative and pharmaceutical composition thereof

Imidazol-4-ylmethanols and their uses for preventing and treating primary tumors, metastasis and recurrence of tumors, various symptoms accompanying tumors, prostatic hypertrophy, virilism, hirsutism, male pattern alopecia, precocious puberty, endometriosis, uterine myoma, mastopathy and polycystic ovary syndrome are disclosed.

virilism/xərçəng xəstəliyi

Azole derivative and pharmaceutical composition thereof

Imidazol-4-ylmehanols and their use as inhibitors of steroid C17-20 lyase

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