Subjected to Cryoneurolysis treatment and Neuromuscular training (GLA:D).

Subjected to similar procedures as CRYO, but without freezing temperatures. Subjected to Neuromuscular training (GLA:D).

Chronic Pain

Osteoarthritis, Knee

A cryoprobe will be inserted percutaneously and freeze the target nerves (infrapatellar branch of the saphenous nerve & anterior femoral cutaneous nerve) guided by ultrasound visualization.

Cryoneurolysis

The GLA:D program, is a standard education and exercise program for patients with osteoarthritis in Denmark. The program is performed in groups and with the supervision of an experienced physiotherapist specialized in training of musculoskeletal disorders.

Neuromuscular exercise (GLA:D)

The sham intervention includes a similar procedure but without freezing temperatures.

Sham

Hospital of Southwest Jutland

Cryoneurolysis for the Management of Chronic Pain in Patients With Knee Osteoarthritis

Cryoneurolysis for the Management of Chronic Pain in Patients With Knee Osteoarthritis; A Randomized Controlled Study

NRS consists of a numerical, from 0 to 10, anchored by two verbal descriptors, "no pain" for the score of zero and "worst pain imaginable" for the score of 10. NRS is a self-reported tool where the respondent is asked their current pain intensity.

The outcome is the total number of complete chair stands performed for the duration of the task (one chair stand represents a stand followed by a sit movement).

Pre-defined and unexpected adverse effects

Change in pain type using prespecified pain definitions

The outcome is expressed as speed. i.e. walking distance (40m) divided by the time to perform the task (s).

The outcome is the total time to perform the task (s).

As measured in moment force of the knee extensors (Nm)

EQ5D consists of 5 subscales; Mobility, Self-care, Usual activities, Pain/Discomfort and Anxiety / depression. An health state score is obtained based on the responses from 1-5 in each subscale, from which a single index value is calculated representing patients' overall health state.

EQ5D includes a so called EQ VAS score which is the patients' self-rated health on a 20 cm vertical, visual analogue scale with endpoints labelled "the best health you can imagine" and "the worst health you can imagine".

KOOS consists of 5 subscales; Pain, other Symptoms, Function in daily living (ADL), Function in sport and recreation (Sport/Rec) and knee related Quality of life (QOL). A normalized score (100 indicating no symptoms and 0 indicating extreme symptoms) us calculated for each subscale.

wallerian degeneration/asthenia

Cryoneurolysis for the Management of Chronic Pain in Patients With Knee Osteoarthritis

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