Fatigue

Stroke, Acute

Transient Ischemic Attack

Medical history and details of the vascular incident will be collected from the patient and the medical journal. (Duration: 1hr)
Neuropsychological measures collected using test measures and questionaries (duration approx 45-60 min).

Clinical Assessment

1. MRI scan session, which includes Structural, Quantitative, Functional and Diffusion MRI sequences. (maximum duration: 90 min).

MRI scan

Bispebjerg Hospital

Danish Research Centre for Magnetic Resonance

Microstructure Imaging in Stroke Patients

New Clinical Magnetic Resonance Technologies for Capturing Brain Microstructure Alterations in Patients With Minor Stroke or Transient Ischemic Attack

The study assumes that minor stroke or TIA leads to both axonal Wallerian degeneration and demyelination. These pathological changes in the white matter brain network can be captured with a new microstructural anisotropy MRI measure related to cell density, shapes, and a measure of myelination. Therefore, a new microstructural fractional anisotropy measure is expected to be more sensitive to pathology than traditional estimations using the diffusion tensor models, such as diffusion tensor imaging (DTI). Moreover, the structural MRI measures are expected to correlate with clinical assessment.

Tim Dyrby

Senior Researcher

wallerian degeneration

fatigue

wallerian degeneration/fatigue

Microstructure Imaging in Stroke Patients

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