Circuitry Assessment and Reinforcement Training Effects on Recovery
Ключавыя словы
Рэферат
Апісанне
Neurofeedback, a form of biofeedback, provides a visual and/or audio representation of an individual's neural electrical activity from live EEG recording. Using operant conditioning principles, individuals are trained to increase or reduce patterns of brainwave activity to modify behavior and performance. Although neurofeedback has not yet been investigated as a treatment for aphasia or other communication deficits due to stroke or neurodegenerative disease, it may be effective. Previous studies have observed improvement in cognitive and behavioral measures in those with conditions such as Attention Deficit Disorder and Attention Deficit Hyperactivity Disorder. Furthermore, it has been associated with reduced anxiety and sleep disruption, which both exacerbate language and communication impairments. Research is needed to determine if neurofeedback may be an effective treatment for language disorders such as PPA and post-stroke communication disorders.
It is possible that EEG neurofeedback, which focuses on improving abnormal brainwave patterns, could provide certain therapeutic benefits to individuals with PPA or post-stroke aphasia, either by directly affecting neural networks that underlie language, or more generally by reducing anxiety and inattention through behavioral conditioning. Reduction of anxiety in neurological diseases can be beneficial not only for functional performance but also sleep duration and quality.
Даты
| Апошняя праверка: | 03/31/2020 |
| Упершыню прадстаўлена: | 02/26/2020 |
| Меркаваная колькасць заявак прадстаўлена: | 02/26/2020 |
| Першае паведамленне: | 03/01/2020 |
| Апошняе абнаўленне адпраўлена: | 04/08/2020 |
| Апошняе абнаўленне апублікавана: | 04/09/2020 |
| Фактычная дата пачатку даследавання: | 08/31/2020 |
| Разліковая дата першаснага завяршэння: | 08/31/2025 |
| Разліковая дата завяршэння даследавання: | 08/31/2025 |
Стан альбо хвароба
Ўмяшанне / лячэнне
Device: Active EEG Neurofeedback
Device: Sham Feedback
Фаза
Групы ўзбраенняў
| Рука | Ўмяшанне / лячэнне |
|---|---|
| Experimental: Active EEG Neurofeedback 15 sessions of active EEG neurofeedback at a frequency of 3-5 sessions per week for a duration of 3-5 weeks. | Device: Active EEG Neurofeedback Active EEG neurofeedback |
| Sham Comparator: Sham Feedback 15 sessions of sham neurofeedback at a frequency of 3-5 sessions per week for a duration of 3-5 weeks. | Device: Sham Feedback Sham EEG feedback sessions identical to active sessions except that the feedback given to the participant will not be based on the individual's live EEG activity. |
Крытэрыі прыдатнасці
| Узрост, які мае права на вучобу | 18 Years Каб 18 Years |
| Пол, прыдатны для навучання | All |
| Прымае здаровых валанцёраў | Так |
| Крытэрыі | Inclusion Criteria: - Diagnosis of PPA or aphasia secondary to stroke and presence of naming deficits with confirmation of diagnosis by neurologist - Capable of giving informed consent or indicating another to provide informed consent - Age 18 or older. - If aphasia is secondary to stroke, the stroke must have occurred between 6 months and 5 years prior to enrollment in the study. Exclusion Criteria: - Lack of English proficiency - Not medically stable - Picture naming accuracy above 80% on the Philadelphia Naming Test (PNT) - Prior history of neurologic disease affecting the brain (e.g., brain tumor, multiple sclerosis, traumatic brain injury) other than stroke or PPA and its underlying neurological pathologies: Alzheimer's Disease, Frontotemporal Lobar Degeneration or Dementia with Lewy bodies - Prior history of severe psychiatric illness, developmental disorders or intellectual disability (e.g., PTSD, major depression, bipolar disorder, schizophrenia, obsessive compulsive disorder (OCD), autism spectrum disorders) - Uncorrected severe visual loss or hearing loss by self-report and medical records |
Вынік
Першасныя вынікі
1. Change in Number of content units expressed in the Picture Description Test [Baseline, 1 week following each intervention period and 8 weeks following both intervention periods]
Меры другаснага выніку
1. Change in number of items correctly named on the Philadelphia Naming Test [Baseline, 1 week following each intervention period and 8 weeks following both intervention periods]
2. Change in Controlled Oral Word Association test (COWA) score [Baseline, 1 week following each intervention period and 8 weeks following both intervention periods]
3. Change in quality of sleep as assessed by the Pittsburgh Sleep Quality Index (PSQI) [Baseline, 1 week following each intervention period and 8 weeks following both intervention periods]
4. Change in anxiety as assessed by the State Trait Anxiety Inventory (STAI) [Baseline, 1 week following each intervention period and 8 weeks following both intervention periods]
5. Change in Sleep Medication Dose [Baseline, 1 week following each intervention period and 8 weeks following both intervention periods]
6. Change in Sleep Medication Frequency [Baseline, 1 week following each intervention period and 8 weeks following both intervention periods]
7. Change in absolute power on EEG [Baseline, 1 week following each intervention period and 8 weeks following both intervention periods]
8. Change in peak amplitude frequency on EEG [Baseline, 1 week following each intervention period and 8 weeks following both intervention periods]
9. Change in EEG absolute power z-scores [Baseline, 1 week following each intervention period and 8 weeks following both intervention periods]
10. Change in EEG peak amplitude frequency z-scores [Baseline, 1 week following each intervention period and 8 weeks following both intervention periods]
11. Change in EEG coherence z-scores [Baseline, 1 week following each intervention period and 8 weeks following both intervention periods]
